Amiodarone and pulmonary fibrosis

J. Morera, R. Vidal, F. Morell, J. Ruiz, Ll Bernadó, J. R. Laporte

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10 Citations (Scopus)

Abstract

Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism. © 1983 Springer-Verlag.
Original languageEnglish
Pages (from-to)591-593
JournalEuropean Journal of Clinical Pharmacology
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Sep 1983

Keywords

  • adverse drug effect
  • amiodarone
  • hypersensitivity mechanism
  • pulmonary fibrosis

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