Aminocyclitol-substituted phytoceramides and their effects on iNKT cell stimulation

Youssef Harrak, Carolina M. Barra, Carmen Bedia, Antonio Delgado, A. Raúl Castaño, Amadeu Llebaria

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

(Chemical Equation Presented) Natural born killers: Nonglycosidic α-galactosylceramide (α-GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α-GalCer but with lower potency, and induces the release of IFN and IL-4 in iNKT cell culture causing a biased Th2 cytokine profile response. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)1608-1613
Number of pages6
JournalChemMedChem
Volume4
Issue number10
DOIs
Publication statusPublished - 14 Oct 2009

Keywords

  • Aminocyclitols
  • Cytokines
  • Glycolipids
  • NKT cells
  • α-galactosylceramides

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