Aminocyclitol-substituted phytoceramides and their effects on iNKT cell stimulation

Youssef Harrak; Carolina M. Barra; Carmen Bedia; Antonio Delgado; A. Raúl Castaño; Amadeu Llebaria

doi:10.1002/cmdc.200900193

Aminocyclitol-substituted phytoceramides and their effects on iNKT cell stimulation

Youssef Harrak, Carolina M. Barra, Carmen Bedia, Antonio Delgado, A. Raúl Castaño, Amadeu Llebaria

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

(Chemical Equation Presented) Natural born killers: Nonglycosidic α-galactosylceramide (α-GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α-GalCer but with lower potency, and induces the release of IFN and IL-4 in iNKT cell culture causing a biased Th2 cytokine profile response. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	1608-1613
Number of pages	6
Journal	ChemMedChem
Volume	4
Issue number	10
DOIs	https://doi.org/10.1002/cmdc.200900193
Publication status	Published - 14 Oct 2009

Keywords

Aminocyclitols
Cytokines
Glycolipids
NKT cells
α-galactosylceramides

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10.1002/cmdc.200900193

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title = "Aminocyclitol-substituted phytoceramides and their effects on iNKT cell stimulation",

abstract = "(Chemical Equation Presented) Natural born killers: Nonglycosidic α-galactosylceramide (α-GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α-GalCer but with lower potency, and induces the release of IFN and IL-4 in iNKT cell culture causing a biased Th2 cytokine profile response. {\textcopyright} 2009 Wiley-VCH Verlag GmbH & Co. KGaA.",

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AU - Harrak, Youssef

AU - Barra, Carolina M.

AU - Bedia, Carmen

AU - Delgado, Antonio

AU - Castaño, A. Raúl

AU - Llebaria, Amadeu

PY - 2009/10/14

Y1 - 2009/10/14

N2 - (Chemical Equation Presented) Natural born killers: Nonglycosidic α-galactosylceramide (α-GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α-GalCer but with lower potency, and induces the release of IFN and IL-4 in iNKT cell culture causing a biased Th2 cytokine profile response. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Chemical Equation Presented) Natural born killers: Nonglycosidic α-galactosylceramide (α-GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α-GalCer but with lower potency, and induces the release of IFN and IL-4 in iNKT cell culture causing a biased Th2 cytokine profile response. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Aminocyclitols

KW - Cytokines

KW - Glycolipids

KW - NKT cells

KW - α-galactosylceramides

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DO - 10.1002/cmdc.200900193

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EP - 1613

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ER -

Aminocyclitol-substituted phytoceramides and their effects on iNKT cell stimulation

Abstract

Keywords

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