Amino acid determination using screen-printed electrochemical sensors

Majlinda Vasjari; Arben Merkoçi; John P. Hart; Salvador Alegret

doi:10.1007/s00604-005-0361-4

Amino acid determination using screen-printed electrochemical sensors

Majlinda Vasjari, Arben Merkoçi, John P. Hart, Salvador Alegret

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

Abstract

The use of a screen-printed electrochemical sensor (SPES) strip, consisting of a two-electrode system (a carbon working electrode and Ag/AgCl reference electrode), for amino acid determination is reported. The behaviour of the SPES toward cysteine and tyrosine is investigated using linear sweep and hydrodynamic voltammetries. The SPES operate at a lower oxidation potential (vs. Ag/AgCl) compared with traditional carbon and platinum electrodes, in a buffer solution (pH = 7) prepared using 0.1 M phosphates and 0.1 M KCl. The linear response lies between 5 * 10-5 M and 5 * 10-4 M for both amino acids while the sensitivity is 2.95 ± 0.03 μA mM-1 for cysteine and 8.00 ± 0.01 μA mM-1 for tyrosine; the correlation coefficient is higher than 0.9980. The sensors were applied to the analysis of some commercial pharmaceutical samples, and the results suggested that the devices hold promise in this application area. © Springer-Verlag 2005.

Original language	English
Pages (from-to)	233-238
Journal	Microchimica Acta
Volume	150
Issue number	3-4
DOIs	https://doi.org/10.1007/s00604-005-0361-4
Publication status	Published - 1 Jul 2005

Keywords

Amino acids
Cyclic voltammetry
Cysteine
Hydrodynamic voltammetry
Linear sweep voltammetry
Screen-printed electrodes
Tyrosine

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title = "Amino acid determination using screen-printed electrochemical sensors",

abstract = "The use of a screen-printed electrochemical sensor (SPES) strip, consisting of a two-electrode system (a carbon working electrode and Ag/AgCl reference electrode), for amino acid determination is reported. The behaviour of the SPES toward cysteine and tyrosine is investigated using linear sweep and hydrodynamic voltammetries. The SPES operate at a lower oxidation potential (vs. Ag/AgCl) compared with traditional carbon and platinum electrodes, in a buffer solution (pH = 7) prepared using 0.1 M phosphates and 0.1 M KCl. The linear response lies between 5 * 10-5 M and 5 * 10-4 M for both amino acids while the sensitivity is 2.95 ± 0.03 μA mM-1 for cysteine and 8.00 ± 0.01 μA mM-1 for tyrosine; the correlation coefficient is higher than 0.9980. The sensors were applied to the analysis of some commercial pharmaceutical samples, and the results suggested that the devices hold promise in this application area. {\textcopyright} Springer-Verlag 2005.",

keywords = "Amino acids, Cyclic voltammetry, Cysteine, Hydrodynamic voltammetry, Linear sweep voltammetry, Screen-printed electrodes, Tyrosine",

author = "Majlinda Vasjari and Arben Merko{\c c}i and Hart, {John P.} and Salvador Alegret",

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AU - Vasjari, Majlinda

AU - Merkoçi, Arben

AU - Hart, John P.

AU - Alegret, Salvador

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Y1 - 2005/7/1

N2 - The use of a screen-printed electrochemical sensor (SPES) strip, consisting of a two-electrode system (a carbon working electrode and Ag/AgCl reference electrode), for amino acid determination is reported. The behaviour of the SPES toward cysteine and tyrosine is investigated using linear sweep and hydrodynamic voltammetries. The SPES operate at a lower oxidation potential (vs. Ag/AgCl) compared with traditional carbon and platinum electrodes, in a buffer solution (pH = 7) prepared using 0.1 M phosphates and 0.1 M KCl. The linear response lies between 5 * 10-5 M and 5 * 10-4 M for both amino acids while the sensitivity is 2.95 ± 0.03 μA mM-1 for cysteine and 8.00 ± 0.01 μA mM-1 for tyrosine; the correlation coefficient is higher than 0.9980. The sensors were applied to the analysis of some commercial pharmaceutical samples, and the results suggested that the devices hold promise in this application area. © Springer-Verlag 2005.

AB - The use of a screen-printed electrochemical sensor (SPES) strip, consisting of a two-electrode system (a carbon working electrode and Ag/AgCl reference electrode), for amino acid determination is reported. The behaviour of the SPES toward cysteine and tyrosine is investigated using linear sweep and hydrodynamic voltammetries. The SPES operate at a lower oxidation potential (vs. Ag/AgCl) compared with traditional carbon and platinum electrodes, in a buffer solution (pH = 7) prepared using 0.1 M phosphates and 0.1 M KCl. The linear response lies between 5 * 10-5 M and 5 * 10-4 M for both amino acids while the sensitivity is 2.95 ± 0.03 μA mM-1 for cysteine and 8.00 ± 0.01 μA mM-1 for tyrosine; the correlation coefficient is higher than 0.9980. The sensors were applied to the analysis of some commercial pharmaceutical samples, and the results suggested that the devices hold promise in this application area. © Springer-Verlag 2005.

KW - Amino acids

KW - Cyclic voltammetry

KW - Cysteine

KW - Hydrodynamic voltammetry

KW - Linear sweep voltammetry

KW - Screen-printed electrodes

KW - Tyrosine

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DO - 10.1007/s00604-005-0361-4

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