Amine oxidase activities in chemically-induced mammary cancer in the rat.

J. M. Lizcano; E. Escrich; K. F. Tipton; M. Unzeta

Amine oxidase activities in chemically-induced mammary cancer in the rat.

J. M. Lizcano, E. Escrich, K. F. Tipton, M. Unzeta

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(alpha)anthracene (DMBA). It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy. It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.

Original language	English
Pages (from-to)	323-326
Journal	Journal of neural transmission. Supplementum
Volume	32
Publication status	Published - 1 Jan 1990

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title = "Amine oxidase activities in chemically-induced mammary cancer in the rat.",

abstract = "The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(alpha)anthracene (DMBA). It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy. It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.",

author = "Lizcano, {J. M.} and E. Escrich and Tipton, {K. F.} and M. Unzeta",

year = "1990",

month = jan,

day = "1",

language = "English",

volume = "32",

pages = "323--326",

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TY - JOUR

T1 - Amine oxidase activities in chemically-induced mammary cancer in the rat.

AU - Lizcano, J. M.

AU - Escrich, E.

AU - Tipton, K. F.

AU - Unzeta, M.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(alpha)anthracene (DMBA). It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy. It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.

AB - The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(alpha)anthracene (DMBA). It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy. It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.

M3 - Article

VL - 32

SP - 323

EP - 326

ER -

Amine oxidase activities in chemically-induced mammary cancer in the rat.

Abstract

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