Altered slow (<1 Hz) and fast (beta and gamma) neocortical oscillations in the 3xTg-AD mouse model of Alzheimer's disease under anesthesia

Patricia Castano-Prat, Lorena Perez-Mendez, Maria Perez-Zabalza, Coral Sanfeliu, Lydia Giménez-Llort, Maria V. Sanchez-Vives

Research output: Contribution to journalArticleResearch

9 Citations (Scopus)

Abstract

© 2019 The Authors The 3xTg-AD mouse model reproduces the main features associated with the etiology of familial Alzheimer's disease (AD). To investigate whether these features imply functional cortical network alterations and their evolution with age, we studied spontaneous slow oscillations, activity that integrates cellular and network properties. We quantified different parameters of the emergent slow oscillations—alternating Up and Down states—and of the embedded beta-gamma rhythms of 3xTg-AD and wild-type mice at 7 and 20 months of age. Most group differences occurred at 20 months of age: 3xTg-AD mice presented lower oscillatory frequency, higher cycle variability, and reduced relative (Up/Down) firing rate with respect to controls. The high-frequency analysis revealed a shift toward lower frequencies in older 3xTg-AD animals, reminiscent of one of the electroencephalography hallmarks of patients with AD. This first systematic characterization of the cortical emergent rhythms in 3xTg-AD strain provides insights into the network mechanisms underlying associated network activity alterations.
Original languageEnglish
Pages (from-to)142-151
JournalNeurobiology of Aging
Volume79
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Aging
  • Alzheimer disease
  • Cerebral cortex
  • Excitability
  • Gamma oscillations
  • Gamma rhythm
  • Slow oscillations
  • Transgenic model
  • Up states

Fingerprint Dive into the research topics of 'Altered slow (<1 Hz) and fast (beta and gamma) neocortical oscillations in the 3xTg-AD mouse model of Alzheimer's disease under anesthesia'. Together they form a unique fingerprint.

Cite this