Allogeneic stem cell transplantation in the era of novel therapies for acute lymphoblastic leukaemia

Pere Barba; Izaskun Elorza

doi:10.1016/j.medcli.2019.01.017

Allogeneic stem cell transplantation in the era of novel therapies for acute lymphoblastic leukaemia

Pere Barba, Izaskun Elorza

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

Abstract

© 2019 Elsevier España, S.L.U. Immunotherapy is changing the treatment of acute lymphoblastic leukaemia (ALL) in adults and children. However, regardless of these new therapies, allogeneic hematopoietic cell transplantation (allo-HCT) still play a key role in the treatment of ALL, although it is uncertain how these new therapies will impact on the transplant procedure and indications. This article reviews the indications of allo-HCT for children and adults diagnosed with ALL, the different sources and conditioning regimens for transplantation as well as the role of measurable residual diseases pre- and post-HCT in the era of the new therapies for ALL.

Original language	English
Pages (from-to)	28-34
Journal	Medicina Clinica
Volume	153
Issue number	1
DOIs	https://doi.org/10.1016/j.medcli.2019.01.017
Publication status	Published - 5 Jul 2019

Keywords

Acute lymphoblastic leukaemia
Allogeneic transplantation
CAR-T
Immunotherapy
Monoclonal antibodies

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N2 - © 2019 Elsevier España, S.L.U. Immunotherapy is changing the treatment of acute lymphoblastic leukaemia (ALL) in adults and children. However, regardless of these new therapies, allogeneic hematopoietic cell transplantation (allo-HCT) still play a key role in the treatment of ALL, although it is uncertain how these new therapies will impact on the transplant procedure and indications. This article reviews the indications of allo-HCT for children and adults diagnosed with ALL, the different sources and conditioning regimens for transplantation as well as the role of measurable residual diseases pre- and post-HCT in the era of the new therapies for ALL.

AB - © 2019 Elsevier España, S.L.U. Immunotherapy is changing the treatment of acute lymphoblastic leukaemia (ALL) in adults and children. However, regardless of these new therapies, allogeneic hematopoietic cell transplantation (allo-HCT) still play a key role in the treatment of ALL, although it is uncertain how these new therapies will impact on the transplant procedure and indications. This article reviews the indications of allo-HCT for children and adults diagnosed with ALL, the different sources and conditioning regimens for transplantation as well as the role of measurable residual diseases pre- and post-HCT in the era of the new therapies for ALL.

KW - Acute lymphoblastic leukaemia

KW - Allogeneic transplantation

KW - CAR-T

KW - Immunotherapy

KW - Monoclonal antibodies

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