TY - JOUR
T1 - Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study
AU - Peremiquel-Trillas, Paula
AU - Benavente, Yolanda
AU - Martín-Bustamante, Mayte
AU - Casabonne, Delphine
AU - Pérez-Gómez, Beatriz
AU - Gómez-Acebo, Inés
AU - Oliete-Canela, Anna
AU - Diéguez-Rodríguez, Marta
AU - Tusquets, Ignasi
AU - Amiano, Pilar
AU - Mengual, Lourdes
AU - Ardanaz, Eva
AU - Capelo, Rocío
AU - Molina de la Torre, Antonio J.
AU - Salas Trejo, Dolores
AU - Fernández-Tardón, Guillermo
AU - Lope, Virginia
AU - Jimenez-Moleon, José J.
AU - Marcos-Gragera, Rafael
AU - Dierssen-Sotos, Trinidad
AU - Azpiri, Mikel
AU - Muñoz, Montse
AU - Guevara, Marcela
AU - Fernández-Villa, Tania
AU - Molina-Barceló, Ana
AU - Aragonés, Nuria
AU - Pollán, Marina
AU - Castaño-Vinyals, Gemma
AU - Alguacil, Juan
AU - Kogevinas, Manolis
AU - de Sanjosé, Silvia
AU - Costas, Laura
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2018 The Authors Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.
AB - © 2018 The Authors Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.
KW - Alkylphenolic compounds
KW - Alkylphenols
KW - Breast cancer
KW - Job-exposure matrix
KW - Occupational exposure
KW - Prostate cancer
U2 - https://doi.org/10.1016/j.envint.2018.12.007
DO - https://doi.org/10.1016/j.envint.2018.12.007
M3 - Article
C2 - 30553564
VL - 122
SP - 389
EP - 399
JO - Environmental International
JF - Environmental International
SN - 0160-4120
ER -