Alcohol overuse and intracerebral hemorrhage: characteristics and long-term outcome

C. Avellaneda-Gómez, M. Serra Martínez, A. Rodríguez-Campello, Angel Javier Ois, E. Cuadrado-Godia, E. Giralt-Steinhauer, R. Vivanco-Hidalgo, J. Jiménez-Conde, A. Gómez-González, P. de Ceballos Cerrajería, A. Zabalza de Torres, M. Mola-Caminal, C. Soriano-Tárraga, J. Roquer

Research output: Contribution to journalArticleResearch

2 Citations (Scopus)

Abstract

© 2018 EAN Background and purpose: Alcohol overuse (AOu) is considered an important risk factor for spontaneous intracerebral hemorrhage (ICH). The clinical and outcome characteristics of these patients (AOu-ICH) are not well known. Methods: All patients with ICH admitted to a single university tertiary stroke center were prospectively studied from May 2005 to May 2015. Demographic profiles, radiologic characteristics and clinical outcomes of patients with acute ICH and previous AOu (>40 g/day or >300 g/week) were analyzed. Results: During the study period, 555 patients with spontaneous primary ICH met the inclusion criteria. A total of 81 patients (14.6%) reported AOu (24.3% of men vs. 3.1% of women; P < 0.0001; mean age, 63 years old for AOu vs. 74 years old for non-AOu; P < 0.0001). Of the classic cardiovascular risk factors, only smoking was associated with AOu (63% vs. 12.2% of non-AOu; P < 0.0001). Initial severity and hematoma volume were similar in both groups, with no observed differences in stroke care or in-hospital medical complications. Patients with AOu had worse outcome (modified Rankin Scale score, 3–6 points) than patients without AOu at 3 months [odds ratio (OR), 2.50; 95% confidence interval (CI), 1.32–4.75; P = 0.005] and 12 months (OR, 2.47; 95% CI, 1.23–5.00; P = 0.011). A similar trend was observed at 5 years (OR, 2.48; 95% CI, 0.96–6.39; P = 0.059). Conclusions: Alcohol overuse was present in 14.6% of patients with ICH, who were predominantly male, smokers and a mean of 11 years younger than the non-AOu group. Despite a lack of differences in initial clinical severity, stroke care and early medical complications, patients with AOu had worse short- and long-term outcomes.
Original languageEnglish
Pages (from-to)1358-1364
JournalEuropean Journal of Neurology
Volume25
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • acute cerebral hemorrhage
  • alcohol overuse
  • heavy alcohol intake
  • hemorrhagic stroke
  • intracerebral hemorrhage
  • outcome

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