TY - JOUR
T1 - Alcohol overuse and intracerebral hemorrhage: characteristics and long-term outcome
AU - Avellaneda-Gómez, C.
AU - Serra Martínez, M.
AU - Rodríguez-Campello, A.
AU - Ois, Angel Javier
AU - Cuadrado-Godia, E.
AU - Giralt-Steinhauer, E.
AU - Vivanco-Hidalgo, R.
AU - Jiménez-Conde, J.
AU - Gómez-González, A.
AU - de Ceballos Cerrajería, P.
AU - Zabalza de Torres, A.
AU - Mola-Caminal, M.
AU - Soriano-Tárraga, C.
AU - Roquer, J.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - © 2018 EAN Background and purpose: Alcohol overuse (AOu) is considered an important risk factor for spontaneous intracerebral hemorrhage (ICH). The clinical and outcome characteristics of these patients (AOu-ICH) are not well known. Methods: All patients with ICH admitted to a single university tertiary stroke center were prospectively studied from May 2005 to May 2015. Demographic profiles, radiologic characteristics and clinical outcomes of patients with acute ICH and previous AOu (>40 g/day or >300 g/week) were analyzed. Results: During the study period, 555 patients with spontaneous primary ICH met the inclusion criteria. A total of 81 patients (14.6%) reported AOu (24.3% of men vs. 3.1% of women; P < 0.0001; mean age, 63 years old for AOu vs. 74 years old for non-AOu; P < 0.0001). Of the classic cardiovascular risk factors, only smoking was associated with AOu (63% vs. 12.2% of non-AOu; P < 0.0001). Initial severity and hematoma volume were similar in both groups, with no observed differences in stroke care or in-hospital medical complications. Patients with AOu had worse outcome (modified Rankin Scale score, 3–6 points) than patients without AOu at 3 months [odds ratio (OR), 2.50; 95% confidence interval (CI), 1.32–4.75; P = 0.005] and 12 months (OR, 2.47; 95% CI, 1.23–5.00; P = 0.011). A similar trend was observed at 5 years (OR, 2.48; 95% CI, 0.96–6.39; P = 0.059). Conclusions: Alcohol overuse was present in 14.6% of patients with ICH, who were predominantly male, smokers and a mean of 11 years younger than the non-AOu group. Despite a lack of differences in initial clinical severity, stroke care and early medical complications, patients with AOu had worse short- and long-term outcomes.
AB - © 2018 EAN Background and purpose: Alcohol overuse (AOu) is considered an important risk factor for spontaneous intracerebral hemorrhage (ICH). The clinical and outcome characteristics of these patients (AOu-ICH) are not well known. Methods: All patients with ICH admitted to a single university tertiary stroke center were prospectively studied from May 2005 to May 2015. Demographic profiles, radiologic characteristics and clinical outcomes of patients with acute ICH and previous AOu (>40 g/day or >300 g/week) were analyzed. Results: During the study period, 555 patients with spontaneous primary ICH met the inclusion criteria. A total of 81 patients (14.6%) reported AOu (24.3% of men vs. 3.1% of women; P < 0.0001; mean age, 63 years old for AOu vs. 74 years old for non-AOu; P < 0.0001). Of the classic cardiovascular risk factors, only smoking was associated with AOu (63% vs. 12.2% of non-AOu; P < 0.0001). Initial severity and hematoma volume were similar in both groups, with no observed differences in stroke care or in-hospital medical complications. Patients with AOu had worse outcome (modified Rankin Scale score, 3–6 points) than patients without AOu at 3 months [odds ratio (OR), 2.50; 95% confidence interval (CI), 1.32–4.75; P = 0.005] and 12 months (OR, 2.47; 95% CI, 1.23–5.00; P = 0.011). A similar trend was observed at 5 years (OR, 2.48; 95% CI, 0.96–6.39; P = 0.059). Conclusions: Alcohol overuse was present in 14.6% of patients with ICH, who were predominantly male, smokers and a mean of 11 years younger than the non-AOu group. Despite a lack of differences in initial clinical severity, stroke care and early medical complications, patients with AOu had worse short- and long-term outcomes.
KW - acute cerebral hemorrhage
KW - alcohol overuse
KW - heavy alcohol intake
KW - hemorrhagic stroke
KW - intracerebral hemorrhage
KW - outcome
U2 - 10.1111/ene.13734
DO - 10.1111/ene.13734
M3 - Article
C2 - 29938871
VL - 25
SP - 1358
EP - 1364
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
ER -