AIM/CD5L: A key protein in the control of immune homeostasis and inflammatory disease

Lucía Sanjurjo*; Gemma Aran*; Nerea Roher; Annabel F. Valledor; Maria-Rosa Sarrias

doi:10.1189/jlb.3RU0215-074R

AIM/CD5L: A key protein in the control of immune homeostasis and inflammatory disease

Lucía Sanjurjo*, Gemma Aran*, Nerea Roher, Annabel F. Valledor, Maria-Rosa Sarrias

Research output: Contribution to journal › Review article › Research › peer-review

85 Citations (Scopus)

Abstract

© Society for Leukocyte Biology. CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as TB and liver cirrhosis.

Original language	English
Pages (from-to)	173-184
Journal	Journal of Leukocyte Biology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1189/jlb.3RU0215-074R
Publication status	Published - 1 Jan 2015

Keywords

Cancer
Macrophage
Metabolic disease
Spα
SRCR domain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1189/jlb.3RU0215-074R

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title = "AIM/CD5L: A key protein in the control of immune homeostasis and inflammatory disease",

abstract = "{\textcopyright} Society for Leukocyte Biology. CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as TB and liver cirrhosis.",

keywords = "Cancer, Macrophage, Metabolic disease, Spα, SRCR domain",

author = "Luc{\'i}a Sanjurjo* and Gemma Aran* and Nerea Roher and Valledor, {Annabel F.} and Maria-Rosa Sarrias",

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doi = "10.1189/jlb.3RU0215-074R",

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T1 - AIM/CD5L: A key protein in the control of immune homeostasis and inflammatory disease

AU - Sanjurjo, Lucía

AU - Aran, Gemma

AU - Roher, Nerea

AU - Valledor, Annabel F.

AU - Sarrias, Maria-Rosa

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © Society for Leukocyte Biology. CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as TB and liver cirrhosis.

AB - © Society for Leukocyte Biology. CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as TB and liver cirrhosis.

KW - Cancer

KW - Macrophage

KW - Metabolic disease

KW - Spα

KW - SRCR domain

U2 - 10.1189/jlb.3RU0215-074R

DO - 10.1189/jlb.3RU0215-074R

M3 - Review article

SN - 0741-5400

VL - 98

SP - 173

EP - 184

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

IS - 2

ER -

AIM/CD5L: A key protein in the control of immune homeostasis and inflammatory disease

Abstract

Keywords

UN SDGs

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