TY - JOUR
T1 - Aggrescan3D standalone package for structure-based prediction of protein aggregation properties
AU - Kuriata, Aleksander
AU - Iglesias, Valentin
AU - Kurcinski, Mateusz
AU - Ventura, Salvador
AU - Kmiecik, Sebastian
PY - 2019/10/1
Y1 - 2019/10/1
N2 - © 2019 The Author(s). Published by Oxford University Press. All rights reserved. Summary: Aggrescan3D (A3D) standalone is a multiplatform Python package for structure-based prediction of protein aggregation properties and rational design of protein solubility. A3D allows the re-design of protein solubility by combining structural aggregation propensity and stability predictions, as demonstrated by a recent experimental study. It also enables predicting the impact of protein conformational fluctuations on the aggregation properties. The standalone A3D version is an upgrade of the original web server implementation - it introduces a number of customizable options, automated analysis of multiple mutations and offers a flexible computational framework for merging it with other computational tools. Availability and implementation: A3D standalone is distributed under the MIT license, which is free for academic and non-profit users. It is implemented in Python. The A3D standalone source code, wiki with documentation and examples of use, and installation instructions for Linux, macOS and Windows are available in the A3D standalone repository at https://bitbucket.org/lcbio/aggrescan3d.
AB - © 2019 The Author(s). Published by Oxford University Press. All rights reserved. Summary: Aggrescan3D (A3D) standalone is a multiplatform Python package for structure-based prediction of protein aggregation properties and rational design of protein solubility. A3D allows the re-design of protein solubility by combining structural aggregation propensity and stability predictions, as demonstrated by a recent experimental study. It also enables predicting the impact of protein conformational fluctuations on the aggregation properties. The standalone A3D version is an upgrade of the original web server implementation - it introduces a number of customizable options, automated analysis of multiple mutations and offers a flexible computational framework for merging it with other computational tools. Availability and implementation: A3D standalone is distributed under the MIT license, which is free for academic and non-profit users. It is implemented in Python. The A3D standalone source code, wiki with documentation and examples of use, and installation instructions for Linux, macOS and Windows are available in the A3D standalone repository at https://bitbucket.org/lcbio/aggrescan3d.
U2 - 10.1093/bioinformatics/btz143
DO - 10.1093/bioinformatics/btz143
M3 - Article
C2 - 30825368
VL - 35
SP - 3834
EP - 3835
ER -