Age and gender effects on 15 platelet phenotypes in a Spanish population

Miquel Vázquez-Santiago, Andrey Ziyatdinov, Núria Pujol-Moix, Helena Brunel, Agnès Morera, José Manuel Soria, Juan Carlos Souto

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9 Citations (Scopus)


© 2016 Elsevier Ltd. Introduction: Several studies have analysed the platelet parameters in human blood, nevertheless there are no extensive analyses on the less common platelet phenotypes. The main objective of our study is to evaluate the age and gender effects on 15 platelet phenotypes. Methods: We studied 804 individuals, ranging in age from 2 to 93 years, included in the Genetic Analysis of Idiopathic Thrombophilia 2 (GAIT 2) Project. The 15 platelet phenotypes analysed were the platelets counts, platelet volumes, plateletcrits, immature platelet fraction (IPF) and platelet function assay (PFA). A regression-based method was used to evaluate the age and gender effects on these phenotypes. Results: Our results were consistent with the previously reported results regarding platelet counts and plateletcrit (PCT). They showed a decrease with increasing age. The mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) increased with age, but did not present any gender effect. All the IPF phenotypes increased with age, whereas the PFA phenotypes did not show any relation to age or gender. Discussion: To sum up, our study provides a comprehensive analysis of the age and gender effects on the platelet phenotypes in a family-base sample. Our results suggest more reasonable age stratification into two distinct groups: childhood, ranging from 2 to 12 years, and the mature group, from 13 to 93 years. Moreover, the PFA phenotypes were maintained constant while the platelet counts, the MPV and IPF levels vary with age.
Original languageEnglish
Pages (from-to)226-233
JournalComputers in Biology and Medicine
Publication statusPublished - 1 Feb 2016


  • Age
  • Gender
  • Immature platelet fraction (IPF)
  • Platelet counts
  • Platelet function assay (PFA)
  • Platelet indices


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