TY - JOUR
T1 - Affective versus first-episode non-affective first-episode psychoses: A longitudinal study
AU - Torrent, C.
AU - Reinares, M.
AU - Martinez-Arán, A.
AU - Cabrera, B.
AU - Amoretti, S.
AU - Corripio, I.
AU - Contreras, F.
AU - Sarró, S.
AU - González-Pinto, A.
AU - Lobo, A.
AU - Cuesta, M. J.
AU - Sánchez-Torres, A.
AU - Bergé, D.
AU - Castro-Fornieles, J.
AU - Moreno, C.
AU - Bernardo, M.
AU - Vieta, E.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - © 2018 Elsevier B.V. Objective: This study aimed to assess (1) whether there were clinical, neuropsychological and functional differences between and within affective and non-affective psychoses at baseline and two years-follow-up and (2) to explore clinical and neuropsychological predictors of psychosocial functioning in the whole sample. Method: This is a subanalysis from a multicentre, naturalistic, longitudinal prospective study (‘Phenotype-genotype and environmental interaction. Application of a predictive model in first psychotic episodes’). The sample consisted of 192 patients with a first psychotic episode (FEP): 142 with non-affective psychoses and 50 with affective psychoses. Student t-tests, paired t-tests, Pearson correlations, ANOVAs and regression analyses were performed. Results: At baseline, the groups differed in perseverative errors (WCST), Premorbid Adjustment Scale (PAS), family history of psychiatric disorder, negative (PANSS) and manic symptoms (YMRS). At two years follow-up, the groups differed in all the PANSS subscales and in depressive symptoms assessed by the MADRS. When the whole sample was considered, the regression model which best explained the estimated variance in functioning at follow-up (41%) was composed by PANSS total score and verbal fluency assessed by the FAS (COWAT). Conclusions: We found clinical and neurocognitive differences at baseline which decreased in the follow-up. Reduced performances at baseline in executive functions in combination with symptom severity (PANSS) were predictors of FEP patients’ poor functional outcome.
AB - © 2018 Elsevier B.V. Objective: This study aimed to assess (1) whether there were clinical, neuropsychological and functional differences between and within affective and non-affective psychoses at baseline and two years-follow-up and (2) to explore clinical and neuropsychological predictors of psychosocial functioning in the whole sample. Method: This is a subanalysis from a multicentre, naturalistic, longitudinal prospective study (‘Phenotype-genotype and environmental interaction. Application of a predictive model in first psychotic episodes’). The sample consisted of 192 patients with a first psychotic episode (FEP): 142 with non-affective psychoses and 50 with affective psychoses. Student t-tests, paired t-tests, Pearson correlations, ANOVAs and regression analyses were performed. Results: At baseline, the groups differed in perseverative errors (WCST), Premorbid Adjustment Scale (PAS), family history of psychiatric disorder, negative (PANSS) and manic symptoms (YMRS). At two years follow-up, the groups differed in all the PANSS subscales and in depressive symptoms assessed by the MADRS. When the whole sample was considered, the regression model which best explained the estimated variance in functioning at follow-up (41%) was composed by PANSS total score and verbal fluency assessed by the FAS (COWAT). Conclusions: We found clinical and neurocognitive differences at baseline which decreased in the follow-up. Reduced performances at baseline in executive functions in combination with symptom severity (PANSS) were predictors of FEP patients’ poor functional outcome.
KW - Bipolar disorder
KW - First episode
KW - longitudinal study
KW - Mania
KW - Psychosis
KW - Schizophrenia
U2 - 10.1016/j.jad.2018.06.005
DO - 10.1016/j.jad.2018.06.005
M3 - Article
C2 - 29902733
VL - 238
SP - 297
EP - 304
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -