Aequorin-expressing yeast emits light under electric control

Cristina Vilanova, Ángeles Hueso, Carles Palanca, Guillem Marco, Miguel Pitarch, Eduardo Otero, Juny Crespo, Jerzy Szablowski, Sara Rivera, Laura Domínguez-Escribà, Emilio Navarro, Arnau Montagud, Pedro Fernández de Córdoba, Asier González, Joaquín Ariño, Andrés Moya, Javier Urchueguía, Manuel Porcar

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)


In this study, we show the use of direct external electrical stimulation of a jellyfish luminescent calcium-activated protein, aequorin, expressed in a transgenic yeast strain. Yeast cultures were electrically stimulated through two electrodes coupled to a standard power generator. Even low (1.5. V) electric pulses triggered a rapid light peak and serial light pulses were obtained after electric pulses were applied periodically, suggesting that the system is re-enacted after a short refraction time. These results open up a new scenario, in the very interphase between synthetic biology and cybernetics, in which complex cellular behavior might be subjected to electrical control. © 2011 Elsevier B.V.
Original languageEnglish
Pages (from-to)93-95
JournalJournal of Biotechnology
Publication statusPublished - 20 Mar 2011


  • Aequorin
  • Bioelectronics
  • Bioluminescence
  • Synthetic biology
  • Yeast electro-stimulation


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