TY - JOUR
T1 - Advances and gaps in SARS-CoV-2 infection models.
AU - Segales Coma, Joaquim
PY - 2022/1/13
Y1 - 2022/1/13
N2 - The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.
AB - The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.
UR - https://doi.org/10.1371/journal.ppat.1010161
UR - http://www.scopus.com/inward/record.url?scp=85123322020&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/d8dafe6f-fa36-32c8-8694-d99a8bd50cc1/
U2 - 10.1371/journal.ppat.1010161
DO - 10.1371/journal.ppat.1010161
M3 - Review article
C2 - 35025969
SN - 1553-7366
VL - 18
JO - PLoS Pathogens
JF - PLoS Pathogens
IS - 1
ER -
