Adult-specific Reelin expression alters striatal neuronal organization : implications for neuropsychiatric disorders

Miquel Vila Bover, Mònica Pardo, Sara Gregorio, Enrica Montalban, Lluís Pujadas, Alba Elias-Tersa, Nuria Masachs, Alba Vílchez-Acosta, Annabelle Parent, Carme Auladell, Jean-Antoine Girault, Angus C. Nairn, Yasmina Manso Sanz, Eduardo Soriano García

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. Moreover, heterozygous reeler mice exhibit features reminiscent of these disorders, while overexpression of Reelin protects against its manifestation. However, how Reelin influences the structure and circuits of the striatal complex, a key region for the above-mentioned disorders, is far from being understood, especially when altered Reelin expression levels are found at adult stages. In the present study, we took advantage of complementary conditional gain- and loss-of-function mouse models to investigate how Reelin levels may modify adult brain striatal structure and neuronal composition. Using immunohistochemical techniques, we determined that Reelin does not seem to influence the striatal patch and matrix organization (studied by μ-opioid receptor immunohistochemistry) nor the density of medium spiny neurons (MSNs, studied with DARPP-32). We show that overexpression of Reelin leads to increased numbers of striatal parvalbumin- and cholinergic-interneurons, and to a slight increase in tyrosine hydroxylase-positive projections. We conclude that increased Reelin levels might modulate the numbers of striatal interneurons and the density of the nigrostriatal dopaminergic projections, suggesting that these changes may be involved in the protection of Reelin against neuropsychiatric disorders.
Original languageEnglish
JournalFrontiers in Cellular Neuroscience
Publication statusPublished - 2023


  • Reelin
  • Striatum
  • Interneurons
  • Dopamine projections
  • Schizophrenia
  • Tourette's syndrome


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