TY - JOUR
T1 - ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation
AU - González-Ortega, Emmanuel
AU - Mena, Maria Pau
AU - Permanyer, Marc
AU - Ballana, Ester
AU - Clotet, Bonaventura
AU - Esté, José A.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
AB - We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
U2 - 10.1128/AAC.00359-10
DO - 10.1128/AAC.00359-10
M3 - Article
VL - 54
SP - 4487
EP - 4492
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 10
ER -
