ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation

Emmanuel González-Ortega, Maria Pau Mena, Marc Permanyer, Ester Ballana, Bonaventura Clotet, José A. Esté

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)4487-4492
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number10
DOIs
Publication statusPublished - 1 Oct 2010

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