Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4

A. Mercadé, M. Pérez-Enciso, L. Varona, E. Alves, J. L. Noguera, A. Sánchez, J. M. Folch

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed. ©2006 American Society of Animal Science. All rights reserved.
Original languageEnglish
Pages (from-to)2907-2913
JournalJournal of Animal Science
Volume84
DOIs
Publication statusPublished - 1 Nov 2006

Keywords

  • FABP4
  • FAT1
  • Fatness
  • Pig
  • QTL

Fingerprint Dive into the research topics of 'Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4'. Together they form a unique fingerprint.

Cite this