TY - JOUR
T1 - Adherence and Satisfaction of Smartphone- and Smartwatch-Based Remote Active Testing and Passive Monitoring in People With Multiple Sclerosis: Nonrandomized Interventional Feasibility Study
AU - Midaglia, Luciana
AU - Mulero, Patricia
AU - Montalban, Xavier
AU - Graves, Jennifer
AU - Hauser, Stephen L.
AU - Julian, Laura
AU - Baker, Michael
AU - Schadrack, Jan
AU - Gossens, Christian
AU - Scotland, Alf
AU - Lipsmeier, Florian
AU - van Beek, Johan
AU - Bernasconi, Corrado
AU - Belachew, Shibeshih
AU - Lindemann, Michael
PY - 2019/8/30
Y1 - 2019/8/30
N2 - ©Luciana Midaglia, Patricia Mulero, Xavier Montalban, Jennifer Graves, Stephen L Hauser, Laura Julian, Michael Baker, Jan Schadrack, Christian Gossens, Alf Scotland, Florian Lipsmeier, Johan van Beek, Corrado Bernasconi, Shibeshih Belachew, Michael Lindemann. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.08.2019. BACKGROUND: Current clinical assessments of people with multiple sclerosis are episodic and may miss critical features of functional fluctuations between visits. OBJECTIVE: The goal of the research was to assess the feasibility of remote active testing and passive monitoring using smartphones and smartwatch technology in persosns with multiple sclerosis with respect to adherence and satisfaction with the FLOODLIGHT test battery. METHODS: Persons with multiple sclerosis (aged 20 to 57 years; Expanded Disability Status Scale 0-5.5; n=76) and healthy controls (n=25) performed the FLOODLIGHT test battery, comprising active tests (daily, weekly, every two weeks, or on demand) and passive monitoring (sensor-based gait and mobility) for 24 weeks using a smartphone and smartwatch. The primary analysis assessed adherence (proportion of weeks with at least 3 days of completed testing and 4 hours per day passive monitoring) and questionnaire-based satisfaction. In-clinic assessments (clinical and magnetic resonance imaging) were performed. RESULTS: Persons with multiple sclerosis showed 70% (16.68/24 weeks) adherence to active tests and 79% (18.89/24 weeks) to passive monitoring; satisfaction score was on average 73.7 out of 100. Neither adherence nor satisfaction was associated with specific population characteristics. Test-battery assessments had an at least acceptable impact on daily activities in over 80% (61/72) of persons with multiple sclerosis. CONCLUSIONS: Persons with multiple sclerosis were engaged and satisfied with the FLOODLIGHT test battery. FLOODLIGHT sensor-based measures may enable continuous assessment of multiple sclerosis disease in clinical trials and real-world settings. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02952911; https://clinicaltrials.gov/ct2/show/NCT02952911.
AB - ©Luciana Midaglia, Patricia Mulero, Xavier Montalban, Jennifer Graves, Stephen L Hauser, Laura Julian, Michael Baker, Jan Schadrack, Christian Gossens, Alf Scotland, Florian Lipsmeier, Johan van Beek, Corrado Bernasconi, Shibeshih Belachew, Michael Lindemann. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.08.2019. BACKGROUND: Current clinical assessments of people with multiple sclerosis are episodic and may miss critical features of functional fluctuations between visits. OBJECTIVE: The goal of the research was to assess the feasibility of remote active testing and passive monitoring using smartphones and smartwatch technology in persosns with multiple sclerosis with respect to adherence and satisfaction with the FLOODLIGHT test battery. METHODS: Persons with multiple sclerosis (aged 20 to 57 years; Expanded Disability Status Scale 0-5.5; n=76) and healthy controls (n=25) performed the FLOODLIGHT test battery, comprising active tests (daily, weekly, every two weeks, or on demand) and passive monitoring (sensor-based gait and mobility) for 24 weeks using a smartphone and smartwatch. The primary analysis assessed adherence (proportion of weeks with at least 3 days of completed testing and 4 hours per day passive monitoring) and questionnaire-based satisfaction. In-clinic assessments (clinical and magnetic resonance imaging) were performed. RESULTS: Persons with multiple sclerosis showed 70% (16.68/24 weeks) adherence to active tests and 79% (18.89/24 weeks) to passive monitoring; satisfaction score was on average 73.7 out of 100. Neither adherence nor satisfaction was associated with specific population characteristics. Test-battery assessments had an at least acceptable impact on daily activities in over 80% (61/72) of persons with multiple sclerosis. CONCLUSIONS: Persons with multiple sclerosis were engaged and satisfied with the FLOODLIGHT test battery. FLOODLIGHT sensor-based measures may enable continuous assessment of multiple sclerosis disease in clinical trials and real-world settings. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02952911; https://clinicaltrials.gov/ct2/show/NCT02952911.
KW - mobile phone
KW - multiple sclerosis
KW - patient adherence
KW - patient satisfaction
KW - smartphone
KW - wearable electronic devices
UR - https://ddd.uab.cat/data/record/222778
U2 - https://doi.org/10.2196/14863
DO - https://doi.org/10.2196/14863
M3 - Article
C2 - 31471961
VL - 21
SP - e14863
JO - Journal of Medical Internet Research
JF - Journal of Medical Internet Research
SN - 1439-4456
ER -