Adding banding ligation is effective as rescue therapy to prevent variceal rebleeding in haemodynamic non-responders to pharmacological therapy

Antonio González, Salvador Augustin, Joan Dot, Mercedes Pérez, Monder Abu-Suboh, Alejandro Romero, Antoni Segarra, Josep Ramón Armengol, Rafael Esteban, Jaime Guardia, Joan Genescà

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Background: It is unknown which is the best therapy to treat haemodynamic non-responders to pharmacological therapy after variceal bleeding. Aim: To evaluate the efficacy of adding banding ligation to drugs to prevent variceal rebleeding in haemodynamic non-responders to drugs. Methods: Fifty-three cirrhotic patients with variceal bleeding underwent a hepatic venous pressure gradient (HVPG) measurement 5 days after the episode. Nadolol and nitrates were then titrated to maximum tolerated doses. A second HVPG was taken 14 days later. Responders (HVPG ≤12. mm. Hg or ≥20% decrease from baseline) were maintained on drugs and non-responders had banding ligation added to drugs. Results: Mean follow-up was 28 months. In 5 patients the second HVPG could not be performed because of early rebleeding. The remaining 48 patients were classified as responders (n=24) and non-responders (n=24), who had banding added. No baseline differences were observed between groups. Variceal rebleeding occurred in 12% of the 48 patients whose haemodynamic response was assessed. Responders on drug therapy presented a 16% rebleeding rate, whilst non-responders rescued with banding showed an 8% rebleeding rate. Rebleeding-related mortality was not different between groups. Conclusion: In a HVPG-guided strategy, adding banding ligation to drugs is an effective rescue strategy to prevent rebleeding in haemodynamic non-responders to drug therapy. © 2011 Editrice Gastroenterologica Italiana S.r.l..
Original languageEnglish
Pages (from-to)55-60
JournalDigestive and Liver Disease
Volume44
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Hepatic venous pressure gradient
  • Liver cirrhosis
  • Pharmacological therapy
  • Portal hypertension
  • Variceal haemorrhage

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