Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation

Oriel Carreño; María Teresa García-Silva; Ascar García-Campos; Ana Martínez-De Aragõn; Bru Cormand; Alfons MacAya

doi:10.1111/j.1526-4610.2011.02014.x

Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation

Oriel Carreño, María Teresa García-Silva, Ascar García-Campos, Ana Martínez-De Aragõn, Bru Cormand, Alfons MacAya

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

We report the case of a 9-year-old girl with early-onset developmental delay, chronic ataxia and prolonged hemiplegic migraine episodes bringing about progressive deterioration. Two days into one episode, diffusion-weighted magnetic resonance imaging disclosed unilateral striatal abnormal signal consistent with cytotoxic edema, which evolved into atrophy on follow-up scans. Mutational screen of CACNA1A gene identified a de novo p.Tyr1387Cys mutation. © 2011 American Headache Society.

Original language	English
Pages (from-to)	1542-1546
Journal	Headache
Volume	51
Issue number	10
DOIs	https://doi.org/10.1111/j.1526-4610.2011.02014.x
Publication status	Published - 1 Nov 2011

Keywords

CACNA1A
hemiplegic migraine
migraine genetics
striatal necrosis

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10.1111/j.1526-4610.2011.02014.x

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title = "Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation",

abstract = "We report the case of a 9-year-old girl with early-onset developmental delay, chronic ataxia and prolonged hemiplegic migraine episodes bringing about progressive deterioration. Two days into one episode, diffusion-weighted magnetic resonance imaging disclosed unilateral striatal abnormal signal consistent with cytotoxic edema, which evolved into atrophy on follow-up scans. Mutational screen of CACNA1A gene identified a de novo p.Tyr1387Cys mutation. {\textcopyright} 2011 American Headache Society.",

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T1 - Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation

AU - Carreño, Oriel

AU - García-Silva, María Teresa

AU - García-Campos, Ascar

AU - Martínez-De Aragõn, Ana

AU - Cormand, Bru

AU - MacAya, Alfons

PY - 2011/11/1

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N2 - We report the case of a 9-year-old girl with early-onset developmental delay, chronic ataxia and prolonged hemiplegic migraine episodes bringing about progressive deterioration. Two days into one episode, diffusion-weighted magnetic resonance imaging disclosed unilateral striatal abnormal signal consistent with cytotoxic edema, which evolved into atrophy on follow-up scans. Mutational screen of CACNA1A gene identified a de novo p.Tyr1387Cys mutation. © 2011 American Headache Society.

AB - We report the case of a 9-year-old girl with early-onset developmental delay, chronic ataxia and prolonged hemiplegic migraine episodes bringing about progressive deterioration. Two days into one episode, diffusion-weighted magnetic resonance imaging disclosed unilateral striatal abnormal signal consistent with cytotoxic edema, which evolved into atrophy on follow-up scans. Mutational screen of CACNA1A gene identified a de novo p.Tyr1387Cys mutation. © 2011 American Headache Society.

KW - CACNA1A

KW - hemiplegic migraine

KW - migraine genetics

KW - striatal necrosis

U2 - 10.1111/j.1526-4610.2011.02014.x

DO - 10.1111/j.1526-4610.2011.02014.x

M3 - Article

VL - 51

SP - 1542

EP - 1546

JO - Headache

JF - Headache

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