Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation

Oriel Carreño, María Teresa García-Silva, Ascar García-Campos, Ana Martínez-De Aragõn, Bru Cormand, Alfons MacAya

    Research output: Contribution to journalArticleResearchpeer-review

    10 Citations (Scopus)

    Abstract

    We report the case of a 9-year-old girl with early-onset developmental delay, chronic ataxia and prolonged hemiplegic migraine episodes bringing about progressive deterioration. Two days into one episode, diffusion-weighted magnetic resonance imaging disclosed unilateral striatal abnormal signal consistent with cytotoxic edema, which evolved into atrophy on follow-up scans. Mutational screen of CACNA1A gene identified a de novo p.Tyr1387Cys mutation. © 2011 American Headache Society.
    Original languageEnglish
    Pages (from-to)1542-1546
    JournalHeadache
    Volume51
    Issue number10
    DOIs
    Publication statusPublished - 1 Nov 2011

    Keywords

    • CACNA1A
    • hemiplegic migraine
    • migraine genetics
    • striatal necrosis

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