Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.

José Ballarín, Yolanda Arce, Roser Torra Balcells, Montserrat Diaz Encarnación, Felix Manzarbeitia, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno

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39 Citations (Scopus)

Abstract

Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.
Original languageEnglish
Pages (from-to)3408-3411
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume26
Issue number10
DOIs
Publication statusPublished - 1 Jan 2011

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