Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.

José Ballarín; Yolanda Arce; Roser Torra Balcells; Montserrat Diaz Encarnación; Felix Manzarbeitia; Alberto Ortiz; Jesús Egido; Juan Antonio Moreno

doi:10.1093/ndt/gfr391

Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.

José Ballarín, Yolanda Arce, Roser Torra Balcells, Montserrat Diaz Encarnación, Felix Manzarbeitia, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno

Department of Medicine

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45 Citations (Scopus)

Abstract

Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.

Original language	English
Pages (from-to)	3408-3411
Journal	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume	26
Issue number	10
DOIs	https://doi.org/10.1093/ndt/gfr391
Publication status	Published - 1 Jan 2011

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Ballarín, J., Arce, Y., Torra Balcells, R., Diaz Encarnación, M., Manzarbeitia, F., Ortiz, A., Egido, J., & Moreno, J. A. (2011). Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26(10), 3408-3411. https://doi.org/10.1093/ndt/gfr391

Ballarín, José ; Arce, Yolanda ; Torra Balcells, Roser ; Diaz Encarnación, Montserrat ; Manzarbeitia, Felix ; Ortiz, Alberto ; Egido, Jesús ; Moreno, Juan Antonio. / Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression. In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 ; Vol. 26, No. 10. pp. 3408-3411.

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title = "Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.",

abstract = "Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.",

author = "Jos{\'e} Ballar{\'i}n and Yolanda Arce and {Torra Balcells}, Roser and {Diaz Encarnaci{\'o}n}, Montserrat and Felix Manzarbeitia and Alberto Ortiz and Jes{\'u}s Egido and Moreno, {Juan Antonio}",

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Ballarín, J, Arce, Y, Torra Balcells, R, Diaz Encarnación, M, Manzarbeitia, F, Ortiz, A, Egido, J & Moreno, JA 2011, 'Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.', Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 26, no. 10, pp. 3408-3411. https://doi.org/10.1093/ndt/gfr391

Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression. / Ballarín, José; Arce, Yolanda; Torra Balcells, Roser; Diaz Encarnación, Montserrat; Manzarbeitia, Felix; Ortiz, Alberto; Egido, Jesús; Moreno, Juan Antonio.

In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 26, No. 10, 01.01.2011, p. 3408-3411.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.

AU - Ballarín, José

AU - Arce, Yolanda

AU - Torra Balcells, Roser

AU - Diaz Encarnación, Montserrat

AU - Manzarbeitia, Felix

AU - Ortiz, Alberto

AU - Egido, Jesús

AU - Moreno, Juan Antonio

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.

AB - Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.

U2 - 10.1093/ndt/gfr391

DO - 10.1093/ndt/gfr391

M3 - Article

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Ballarín J, Arce Y, Torra Balcells R, Diaz Encarnación M, Manzarbeitia F, Ortiz A et al. Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Jan 1;26(10):3408-3411. https://doi.org/10.1093/ndt/gfr391

Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression.

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