Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats

Mara Dierssen, Frederic Màrmol, Nuria M. Vivas, M. Victòria Clos, Silvia Gascón, Albert Badia

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

The effects of acute treatment with 1,2,3,4-tetrahydro-9-aminoacridine (THA), a 4-aminopyridine derivative clinically effective in Alzheimer's disease, on β-adrenoceptor-linked cyclic AMP accumulation have been investigated in cortical and hippocampal structures of young and middle-aged rats. In a first series of experiments, pretreatment with 2.5 mg/kg THA decreased basal cyclic AMP accumulation. When a phosphodiesterase inhibitor was added to the preparation, THA again decreased cyclic AMP levels in young rats, but failed to significantly modify cyclic AMP accumulation in middle-aged animals. Finally, in isoprenaline-stimulated conditions, acute treatment with tacrine was able to diminish cyclic AMP accumulation in every group of rats. It is suggested that the neurochemical action of THA in mammalian brain is more complex than earlier has been anticipated and may involve an action on β-adrenoceptors. © 1991.
Original languageEnglish
Pages (from-to)51-54
JournalNeuroscience Letters
Volume132
DOIs
Publication statusPublished - 28 Oct 1991

Keywords

  • Adenylate cyclase
  • Aging
  • Cortex
  • Cyclic AMP
  • Hippocampus
  • Tetrahydroaminoacridine
  • β-Adrenoceptor

Fingerprint

Dive into the research topics of 'Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats'. Together they form a unique fingerprint.

Cite this