Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report

G. Vellalta; C. Dopazo; I. Bilbao; L. Castells; G. Sapisochin; J. L. Lázaro; null Montero; M. T. Salcedo; M. Caralt; R. Charco

doi:10.1016/j.transproceed.2015.10.036

Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report

G. Vellalta, C. Dopazo, I. Bilbao, L. Castells, G. Sapisochin, J. L. Lázaro, Montero, M. T. Salcedo, M. Caralt, R. Charco

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3 Citations (Scopus)

Abstract

© 2015 Elsevier Inc. Background Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. Case Report Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late antibody-mediated rejection (AMR). De novo donor-specific antibodies appeared later in a previously negative donor-recipient crossmatch, leading to a rapid deterioration of liver function. Conclusions We highlight the importance of an accurate diagnosis and an early therapeutic intervention. The analysis of this case brings novel and generalizable insights to the differential diagnosis of acute liver failure after LT.

Original language	English
Pages (from-to)	3016-3019
Journal	Transplantation Proceedings
Volume	47
Issue number	10
DOIs	https://doi.org/10.1016/j.transproceed.2015.10.036
Publication status	Published - 1 Dec 2015

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title = "Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report",

abstract = "{\textcopyright} 2015 Elsevier Inc. Background Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. Case Report Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late antibody-mediated rejection (AMR). De novo donor-specific antibodies appeared later in a previously negative donor-recipient crossmatch, leading to a rapid deterioration of liver function. Conclusions We highlight the importance of an accurate diagnosis and an early therapeutic intervention. The analysis of this case brings novel and generalizable insights to the differential diagnosis of acute liver failure after LT.",

author = "G. Vellalta and C. Dopazo and I. Bilbao and L. Castells and G. Sapisochin and L{\'a}zaro, {J. L.} and Montero and Salcedo, {M. T.} and M. Caralt and R. Charco",

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doi = "10.1016/j.transproceed.2015.10.036",

language = "English",

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TY - JOUR

T1 - Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report

AU - Vellalta, G.

AU - Dopazo, C.

AU - Bilbao, I.

AU - Castells, L.

AU - Sapisochin, G.

AU - Lázaro, J. L.

AU - Montero, null

AU - Salcedo, M. T.

AU - Caralt, M.

AU - Charco, R.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - © 2015 Elsevier Inc. Background Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. Case Report Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late antibody-mediated rejection (AMR). De novo donor-specific antibodies appeared later in a previously negative donor-recipient crossmatch, leading to a rapid deterioration of liver function. Conclusions We highlight the importance of an accurate diagnosis and an early therapeutic intervention. The analysis of this case brings novel and generalizable insights to the differential diagnosis of acute liver failure after LT.

AB - © 2015 Elsevier Inc. Background Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. Case Report Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late antibody-mediated rejection (AMR). De novo donor-specific antibodies appeared later in a previously negative donor-recipient crossmatch, leading to a rapid deterioration of liver function. Conclusions We highlight the importance of an accurate diagnosis and an early therapeutic intervention. The analysis of this case brings novel and generalizable insights to the differential diagnosis of acute liver failure after LT.

U2 - 10.1016/j.transproceed.2015.10.036

DO - 10.1016/j.transproceed.2015.10.036

M3 - Article

SN - 0041-1345

VL - 47

SP - 3016

EP - 3019

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 10

ER -

Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report

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