Activation-induced cell death in T lymphocytes from multiple sclerosis patients

Montserrat Moreno, Laura Negrotto, Jordi Río, Rana Moubarak, Isabel Martín, Marta F. Bustamante, Joan X. Comella, Angela Vidal-Jordana, Jennifer Pérez-Boza, Xavier Montalban, Manuel Comabella

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7 Citations (Scopus)

Abstract

Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation. © 2014 Elsevier B.V.
Original languageEnglish
Pages (from-to)51-55
JournalJournal of Neuroimmunology
Volume272
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Activation-induced cell death
  • Apoptosis
  • Caspase 3
  • Fas
  • Multiple sclerosis
  • T lymphocytes

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