Activation-induced cell death in T lymphocytes from multiple sclerosis patients

Montserrat Moreno; Laura Negrotto; Jordi Río; Rana Moubarak; Isabel Martín; Marta F. Bustamante; Joan X. Comella; Angela Vidal-Jordana; Jennifer Pérez-Boza; Xavier Montalban; Manuel Comabella

doi:https://doi.org/10.1016/j.jneuroim.2014.04.007

Activation-induced cell death in T lymphocytes from multiple sclerosis patients

Montserrat Moreno, Laura Negrotto, Jordi Río, Rana Moubarak, Isabel Martín, Marta F. Bustamante, Joan X. Comella, Angela Vidal-Jordana, Jennifer Pérez-Boza, Xavier Montalban, Manuel Comabella

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation. © 2014 Elsevier B.V.

Original language	English
Pages (from-to)	51-55
Journal	Journal of Neuroimmunology
Volume	272
DOIs	https://doi.org/10.1016/j.jneuroim.2014.04.007
Publication status	Published - 1 Jan 2014

Keywords

Activation-induced cell death
Apoptosis
Caspase 3
Fas
Multiple sclerosis
T lymphocytes

Access to Document

https://doi.org/10.1016/j.jneuroim.2014.04.007

Cite this

@article{aa09316a87204232a12a1ba4cf14c0fb,

title = "Activation-induced cell death in T lymphocytes from multiple sclerosis patients",

abstract = "Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation. {\textcopyright} 2014 Elsevier B.V.",

keywords = "Activation-induced cell death, Apoptosis, Caspase 3, Fas, Multiple sclerosis, T lymphocytes",

author = "Montserrat Moreno and Laura Negrotto and Jordi R{\'i}o and Rana Moubarak and Isabel Mart{\'i}n and Bustamante, {Marta F.} and Comella, {Joan X.} and Angela Vidal-Jordana and Jennifer P{\'e}rez-Boza and Xavier Montalban and Manuel Comabella",

year = "2014",

month = jan,

day = "1",

doi = "https://doi.org/10.1016/j.jneuroim.2014.04.007",

language = "English",

volume = "272",

pages = "51--55",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

}

TY - JOUR

T1 - Activation-induced cell death in T lymphocytes from multiple sclerosis patients

AU - Moreno, Montserrat

AU - Negrotto, Laura

AU - Río, Jordi

AU - Moubarak, Rana

AU - Martín, Isabel

AU - Bustamante, Marta F.

AU - Comella, Joan X.

AU - Vidal-Jordana, Angela

AU - Pérez-Boza, Jennifer

AU - Montalban, Xavier

AU - Comabella, Manuel

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation. © 2014 Elsevier B.V.

AB - Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation. © 2014 Elsevier B.V.

KW - Activation-induced cell death

KW - Apoptosis

KW - Caspase 3

KW - Fas

KW - Multiple sclerosis

KW - T lymphocytes

U2 - https://doi.org/10.1016/j.jneuroim.2014.04.007

DO - https://doi.org/10.1016/j.jneuroim.2014.04.007

M3 - Article

SN - 0165-5728

VL - 272

SP - 51

EP - 55

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Activation-induced cell death in T lymphocytes from multiple sclerosis patients

Abstract

Keywords

Access to Document

Fingerprint

Cite this