Activating a Peroxo Ligand for C−O Bond Formation

M. Pilar del Río, Paula Abril, José A. López, Mariona Sodupe, Agustí Lledós, Miguel A. Ciriano, Cristina Tejel

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Dioxygen activation for effective C-O bond formation in the coordination sphere of a metal is a long-standing challenge in chemistry for which the design of catalysts for oxygenations is slowed down by the complicated, and sometimes poorly understood, mechanistic panorama. In this context, olefin-peroxide complexes could be valuable models for the study of such reactions. Herein, we showcase the isolation of rare "Ir(cod)(peroxide)" complexes (cod=1,5-cyclooctadiene) from reactions with oxygen, and then the activation of the peroxide ligand for O-O bond cleavage and C-O bond formation by transfer of a hydrogen atom through proton transfer/electron transfer reactions to give 2-iradaoxetane complexes and water. 2,4,6-Trimethylphenol, 1,4-hydroquinone, and 1,4-cyclohexadiene were used as hydrogen atom donors. These reactions can be key steps in the oxy-functionalization of olefins with oxygen, and they constitute a novel mechanistic pathway for iridium, whose full reaction profile is supported by DFT calculations.

Original languageEnglish
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number10
DOIs
Publication statusPublished - 4 Mar 2019

Keywords

  • 2-iridaoxetanes
  • CARBON-MONOXIDE
  • COMPLEXES
  • DIOXYGEN
  • IRIDIUM
  • MECHANISM
  • O-2 ACTIVATION
  • OLEFIN-OXYGENATION
  • OXIDATION
  • REACTIVITY
  • RHODIUM
  • dioxygen cleavage
  • iridium
  • oxygenation
  • peroxide complexes

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