Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection

Mónica Gordón-Alonso, Vera Rocha-Perugini, Susana Álvarez, Ángeles Ursa, Nuria Izquierdo-Useros, Javier Martinez-Picado, María A. Muñoz-Fernández, Francisco Sánchez-Madrid

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Background: Drebrin binds to F-actin and CXCR4 in T cells. Thus, it is a potential candidate for the modulation of HIV-1 infection. Results: Drebrin and CXCR4 accumulate at viral attachment areas. Drebrin knockdown decreases F-actin polymerization, and increases local profilin accumulation and HIV-1 infection. Conclusion: Drebrin inhibits HIV-1 entry by stabilizing HIV-1-triggered F-actin polymerization. Significance: Modulation of actin dynamics differentially regulates each viral step for an effective viral infection. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)28382-28397
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
Publication statusPublished - 27 Sep 2013

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