Acral Mutilation Syndrome in a Miniature Pinscher

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Acral mutilation syndrome (AMS) is a rare canine hereditary sensory neuropathy that results in progressive mutilation of the distal extremities and which has been reported only in German short-haired pointers, English pointers, English springer spaniels and French spaniels. The present report describes a case of AMS in an 18-month-old female miniature pinscher with progressive self-mutilation of the hind feet. The dog did not respond to any treatment and was humanely destroyed at the age of 30 months. Microscopical findings post mortem were restricted to the nervous system and were compatible with AMS. This is the first case of AMS described in a miniature pinscher. It is not known if the disease was the result of a point mutation in this particular dog or if the miniature pinscher breed will evolve to become a breed predisposed to AMS. © 2010 Elsevier Ltd.
Original languageEnglish
Pages (from-to)235-238
JournalJournal of Comparative Pathology
Issue number2-3
Publication statusPublished - 1 Feb 2011


  • Acral mutilation
  • Dog
  • Sensory neuropathy


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