Few studies have investigated the role of the BDNF-val66met polymorphism in fear conditioning in humans, and previous results have been inconsistent. In the present study, we examined whether the BDNF-val66met was associated with differences in the acquisition and generalization of fear during a differential conditioning paradigm in a large sample of participants (N=141). Using three different indexes of fear learning (fear-potentiated startle, skin conductance response, and online risk ratings) no effects of the BDNF-val66met were found either on the acquisition or the generalization of conditioned fear. Taken together with previous data, our study suggests that the BDNF-val66met polymorphism has no effect on the acquisition or generalization of fear. © 2012 Society for Psychophysiological Research.
|Publication status||Published - 1 Jan 2012|
- Individual differences
Torrents-Rodas, D., Fullana, M. A., Arias, B., Bonillo, A., Caseras, X., Andión, O., Mitjans, M., Fañanás, L., & Torrubia, R. (2012). Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans. Psychophysiology, 49, 713-719. https://doi.org/10.1111/j.1469-8986.2011.01352.x