Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans

David Torrents-Rodas, Miquel A. Fullana, Bárbara Arias, Albert Bonillo, Xavier Caseras, Oscar Andión, Marina Mitjans, Lourdes Fañanás, Rafael Torrubia

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Few studies have investigated the role of the BDNF-val66met polymorphism in fear conditioning in humans, and previous results have been inconsistent. In the present study, we examined whether the BDNF-val66met was associated with differences in the acquisition and generalization of fear during a differential conditioning paradigm in a large sample of participants (N=141). Using three different indexes of fear learning (fear-potentiated startle, skin conductance response, and online risk ratings) no effects of the BDNF-val66met were found either on the acquisition or the generalization of conditioned fear. Taken together with previous data, our study suggests that the BDNF-val66met polymorphism has no effect on the acquisition or generalization of fear. © 2012 Society for Psychophysiological Research.
Original languageEnglish
Pages (from-to)713-719
JournalPsychophysiology
Volume49
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Conditioning
  • Emotion
  • Genetics
  • Individual differences

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