Acoustic-like dynamics of amorphous drugs in the THz regime

E. A.A. Pogna, C. Rodríguez-Tinoco, M. Krisch, J. Rodríguez-Viejo, T. Scopigno

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.
Original languageEnglish
Article number2518
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 20 Sep 2013

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