Accuracy of monoclonal stool tests for determining cure of helicobacter pylori infection after treatment

Xavier Calvet, Sergio Lario, María José Ramírez-Lázaro, Antònia Montserrat, Mariela Quesada, Lynsey Reeves, Helen Masters, David Suárez-Lamas, Marta Gallach, Mireia Miquel, Eva Martínez-Bauer, Isabel Sanfeliu, Ferran Segura

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)


Background: Studies comparing new monoclonal fecal tests for evaluating cure of Helicobacter pylori infection after treatment are scarce. The objective was to compare the diagnostic accuracy of three monoclonal stool tests: two rapid in-office tools -RAPID Hp StAR and ImmunoCard STAT HpSA - and an EIA test - Amplified IDEIA Hp StAR. Materials and methods: Diagnostic reliability of the three tests was evaluated in 88 patients at least 8 weeks after H. pylori treatment. Readings of immunochromatographic tests were performed by two different observers. Sensitivity, specificity, positive and negative predictive values and 95% confidence intervals were calculated. Results: All tests presented similar performance for post-eradication testing. Sensitivity for detecting persistent infection was 100% for both Amplified IDEIA and RAPID Hp StAR and 90% for ImmunoCard STAT HpSA. Respective specificities were 94.9%, 92.3-93.6% and 94.9%. Negative predictive values were very high (100%, 100% and 98.7% respectively). But positive predictive values were lower, ranging from 62.5 to 71.4%. Conclusion: All monoclonal fecal tests in this series presented similar performance in the post-treatment setting. A negative test after treatment adequately predicted cure of the infection. However, nearly a third of tests were false positive, showing a poor predictive yield for persistent infection. © 2010 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)201-205
Issue number3
Publication statusPublished - 1 Jan 2010


  • Helicobacter pylori
  • Immunoassay
  • Post-eradication follow-up
  • Sensitivity and specificity


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