Accuracy of an indirect carbon dioxide Fick method in determination of the cardiac output in critically ill mechanically ventilated patients

We evaluated the accuracy of an indirect CO2 Fick method for measuring cardiac output in 30 critically ill mechanically ventilated patients. When the Fick principle was applied to CO2 using estimated PaCO2, the cardiac output obtained underestimated the thermodilution technique showing a lack of accuracy. However, there was a significant correlation between thermodilution and CO2 rebreathing methods using measured (r=0.92; p<0.001) and estimated (r=0.60; p<0.01) arterial PCO2. The regression equation using measured arterial PCO2 was y=0.59+0.91x, and for estimated arterial PCO2 was y=1.7+0.33x. The results suggest that the CO2 rebreathing method using measured arterial PCO2 may be useful to determine cardiac output in those seriously ill patients on artificial ventilation not requiring right heart catheterization. © 1988 Springer-Verlag.