© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. The mechanism of a trinuclear cooperative dehydrogenative C−N bond-forming reaction is investigated in this work, which avoids the use of chelate-assisting directing groups. Two new highly efficient Ru/Cu co-catalyzed systems were identified, allowing orders of magnitude greater TOFs than the previous state of the art. In-depth kinetic studies were performed in combination with advanced DFT calculations, which reveal a decisive rate-determining trinuclear Ru–Cu cooperative reductive elimination step (CRE).
|Journal||Chemistry - A European Journal|
|Publication status||Published - 12 Oct 2018|
- cooperative reductive elimination
- cross dehydrogenative coupling
- C−H bond activation
- dehydrogenative amination
- trinuclear catalysis