Abnormalities of the Bereitschaftspotential and MRI pallidal signal in non-encephalopathic cirrhotic patients

Jaime Kulisevsky, Joan Conill, Asunción Avila, Jesús pujol, Joaquín Balanzo, Antoni Capdevila

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

In cirrhotic patients, even in the non-encephalopathic state, MRI may show an increased signal in globus pallidus in T1-weighted sequences, the clinical significance of which is still poorly characterized. A dysfunction of the motor circuit of the basal ganglia might be predicted if the increased MRI signal expressed alterations in the globus pallidus activity. We compared the Bereitschaftspotential (BP) in 15 non-encephalopathic cirrhotic patients and 15 age-matched controls and found that the amplitude of the early component and the peak negativity of the BP before the electromyogram onset were significantly reduced in the patient group. The intensity of the pallidal signal was related to the plasma ammonia level but the amplitudes of the BP were not related to the pallidal signal or to ammonia. These findings indicate that a defective activity of the cortical areas implicated in the preparation of movement, not specifically related to the pallidal signal, can be present in cirrhotic patients, even in the non-encephalopathic state. © 1995.
Original languageEnglish
Pages (from-to)425-431
JournalElectroencephalography and Clinical Neurophysiology
Volume94
Issue number6
DOIs
Publication statusPublished - 1 Jan 1995

Keywords

  • Bereitschaftspotential
  • Cirrhosis
  • MRI
  • Non-encephalopathic state
  • Pallidal signal

Fingerprint Dive into the research topics of 'Abnormalities of the Bereitschaftspotential and MRI pallidal signal in non-encephalopathic cirrhotic patients'. Together they form a unique fingerprint.

Cite this