A straightforward synthesis of functionalized cis-perhydroisoquinolin-1-ones

Federica Arioli, Maria Pérez, Celeste Are, Elies Molins, Joan Bosch, Mercedes Amat

    Research output: Contribution to journalArticleResearch


    © 2019 by the authors. Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
    Original languageEnglish
    Article number557
    Publication statusPublished - 3 Feb 2019


    • 5,6-dihydro-2(1H)-pyridone
    • Michael addition
    • Nazarov reagents
    • Perhydroisoquinoline
    • Stereoselectivity

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