© 2019 by the authors. Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
- Michael addition
- Nazarov reagents
Arioli, F., Pérez, M., Are, C., Molins, E., Bosch, J., & Amat, M. (2019). A straightforward synthesis of functionalized cis-perhydroisoquinolin-1-ones. Molecules, 24, . https://doi.org/10.3390/molecules24030557