A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and EGFR-Mutant Non-Small Cell Lung Cancer

Teresa Moran, Vanesa Quiroga, Beatriz Cirauqui, Laia Vila, Maria Gil-Moreno, Enric Carcereny, Mireia Margeli, Ana Muñoz-Marmol, Jose Luis Mate, Jose Maria Velarde, Miguel Angel Molina, Rafael Rosell

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

BACKGROUND: Second primary malignancies (SPM) in the lung are not common in breast cancer (BC) patients. EGFR-mutant lung cancer (LC) is a separate molecular subset, and the co-existence of EGFR-mutant LC and BC has not been explored. We hypothesized that EGFR-mutant LC patients could have higher rates of primary BC than those with EGFR-wild type (WT).

METHODS: We collected data on clinical and molecular characteristics and outcomes of female patients with LC and a previous or simultaneous history of primary BC treated in our hospital from 2008 to 2014.

RESULTS: Data on treatment, follow-up, and EGFR mutation status were available for 356 patients. 17.7% (11/62) of patients with EGFR mutations had BC, compared to 1.02% (3/294) of EGFR-WT patients (p < 0.001). Both tumors were metachronous in 81.8%, with LC diagnosed 9 years after the diagnosis of BC. 5 of the 6 (83.3%) BC patients treated with radiotherapy developed LC in an area within the radiation field. No EGFR mutations were detected in BC tissue and no HER2 expression was detected in LC samples.

CONCLUSION: SPM in the lung and breast occur more frequently among EGFR-mutant compared to EGFR-WT LC patients. Radiotherapy for BC may increase the risk of developing primary LC.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalOncology Research and Treatment
Volume42
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols/therapeutic use
  • Breast/pathology
  • Breast Neoplasms/epidemiology
  • Carcinoma, Non-Small-Cell Lung/epidemiology
  • ErbB Receptors/genetics
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Lung/pathology
  • Lung Neoplasms/epidemiology
  • Mastectomy/methods
  • Middle Aged
  • Mutation
  • Neoplasms, Second Primary/epidemiology
  • Radiotherapy/adverse effects
  • Receptor, ErbB-2/metabolism
  • Retrospective Studies

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