A simple nonequilibrium thermodynamic description of some inhibitors of oxidative phosphorylation

David Jou, Fernando Ferrer

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11 Citations (Scopus)

Abstract

We propose a macroscopic description of some inhibitors of oxidative phosphorylation based on a simple modification of the phenomenological coefficients appearing in the constitutive equations of linear irreversible thermodynamics. In this theoretical model, we consider protonophores, some ATPase inactivators and some electron-chain inhibitors, and we provide quantitative expressions for their consequences on the protonmotive force, oxidation flux and phosphorylation flux as well as on heat generation. © 1985 Academic Press Inc. (London) Ltd.
Original languageEnglish
Pages (from-to)471-488
JournalJournal of Theoretical Biology
Volume117
DOIs
Publication statusPublished - 7 Dec 1985

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