A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection

A. Amoroso; F. Asensi-Botet; A. Pereda; V. Balossini; G. Bona; M. Zaffaroni; A. Bandelloni; A. Coscia; C. Fabris; S. Aime; C. Belloni; G. Bossi; B. Salati; C. Boucher; W. Buffolano; K. Butler; L. Cabero Roura; J. M. Bertran Sanges; P. Cigna; L. M. Ciria; C. Servera Ginard; G. Claret Teruel; C. Fortuny; O. Coll; A. Corrias; R. Ledda; S. Floris; A. De Maria; J. Echeverria; G. Cilla; M. Lanari; E. Tridapalli; V. Venturi; G. Faldella; B. Fischler; A. B. Bohlin; S. Lindgren; G. Lindh; V. Giacomet; M. Merlo; C. Figini; P. Erba; A. Viganò; S. Hannam; G. Mieli-Vergani; A. Hatzakis; C. Inchley; H. O. Fjaerli; A. Maccabruni; M. Marcellini; M. R. Sartorelli; P. Martin Fontelos; A. Mazza; J. Y.Q. Mok; A. Mûr; M. Viñolas; D. M. Paternoster; P. Grella; S. Polywka; I. Quinti; A. M. Casadei; A. Rojahn; A. Berg; R. Rosso; S. Ferrando; D. Bassetti; J. Ruiz Contreras; A. Manzanares; A. Ruiz Extremera; F. Salvini; G. V. Zuccotti; T. Schmitz; I. Grosch-Wörner; C. Feiterna Sperling; T. Piening; A. Vegnente; R. Iorio; A. Versace; S. Garetto; L. Lazier; S. Bressio; C. Riva; A. Alfarano; R. Wejstal; G. Norkrans; A. Zanetti; E. Tanzi; Pier Angelo Tovo; Lucy Pembrey; Marie Louise Newell

A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection

A. Amoroso, F. Asensi-Botet, A. Pereda, V. Balossini, G. Bona, M. Zaffaroni, A. Bandelloni, A. Coscia, C. Fabris, S. Aime, C. Belloni, G. Bossi, B. Salati, C. Boucher, W. Buffolano, K. Butler, L. Cabero Roura, J. M. Bertran Sanges, P. Cigna, L. M. CiriaC. Servera Ginard, G. Claret Teruel, C. Fortuny, O. Coll, A. Corrias, R. Ledda, S. Floris, A. De Maria, J. Echeverria, G. Cilla, M. Lanari, E. Tridapalli, V. Venturi, G. Faldella, B. Fischler, A. B. Bohlin, S. Lindgren, G. Lindh, V. Giacomet, M. Merlo, C. Figini, P. Erba, A. Viganò, S. Hannam, G. Mieli-Vergani, A. Hatzakis, C. Inchley, H. O. Fjaerli, A. Maccabruni, M. Marcellini, M. R. Sartorelli, P. Martin Fontelos, A. Mazza, J. Y.Q. Mok, A. Mûr, M. Viñolas, D. M. Paternoster, P. Grella, S. Polywka, I. Quinti, A. M. Casadei, A. Rojahn, A. Berg, R. Rosso, S. Ferrando, D. Bassetti, J. Ruiz Contreras, A. Manzanares, A. Ruiz Extremera, F. Salvini, G. V. Zuccotti, T. Schmitz, I. Grosch-Wörner, C. Feiterna Sperling, T. Piening, A. Vegnente, R. Iorio, A. Versace, S. Garetto, L. Lazier, S. Bressio, C. Riva, A. Alfarano, R. Wejstal, G. Norkrans, A. Zanetti, E. Tanzi, Pier Angelo Tovo, Lucy Pembrey, Marie Louise Newell

Department of Paediatrics, Obstetrics and Gynaecology and Preventive Medicine and Public Health

Research output: Contribution to journal › Article › Research › peer-review

202 Citations (Scopus)

Abstract

© 2005 by the Infectious Diseases Society of America. All rights reserved. Background. Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified Methods. We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants. Children with ≥2 positive HCV RNA polymerase chain reaction test results and/or anti-HCV antibodies after 18 months of age were considered to be infected. Results. The overall HCV vertical transmission rate was 6.2% (95% confidenc interval [CI], 5.0%–7.5%; 91/1479). Girls were twice as likely to be infected as boys (adjusted odds ratio [OR], 2.07 [95% CI, 1.23–3.48];). P =.006 There was no protective effect of elective cesarean section (CS) delivery on HCV vertical transmission (adjusted OR, 1.46 [95% CI, 0.86–2.48]; P =.16). HCV/human immunodeficienc virus-coinfected women more frequently transmitted HCV than did women with HCV infection only, although the difference was not statistically significan (adjusted OR, 1.82 [95% CI, 0.94–3.52]; P =.08). Maternal history of injection drug use, prematurity, and breast-feeding were not significantl associated with transmission. Transmission occurred more frequently from viremic women, but it also occurred from a few nonviremic women. Conclusions. Our results strongly suggest that women should neither be offered an elective CS nor be discouraged from breast-feeding on the basis of HCV infection alone. The sex association is an intriguing findin that probably reflect biological differences in susceptibility or response to infection.

Original language	English
Pages (from-to)	1872-1879
Journal	Journal of Infectious Diseases
Volume	61
Issue number	4
Publication status	Published - 1 Dec 2005

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Amoroso, A., Asensi-Botet, F., Pereda, A., Balossini, V., Bona, G., Zaffaroni, M., Bandelloni, A., Coscia, A., Fabris, C., Aime, S., Belloni, C., Bossi, G., Salati, B., Boucher, C., Buffolano, W., Butler, K., Cabero Roura, L., Bertran Sanges, J. M., Cigna, P., ... Newell, M. L. (2005). A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection. Journal of Infectious Diseases, 61(4), 1872-1879.

@article{43324bf250dd469dafc10dcdce4f9485,

title = "A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection",

abstract = "{\textcopyright} 2005 by the Infectious Diseases Society of America. All rights reserved. Background. Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified Methods. We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants. Children with ≥2 positive HCV RNA polymerase chain reaction test results and/or anti-HCV antibodies after 18 months of age were considered to be infected. Results. The overall HCV vertical transmission rate was 6.2% (95% confidenc interval [CI], 5.0%–7.5%; 91/1479). Girls were twice as likely to be infected as boys (adjusted odds ratio [OR], 2.07 [95% CI, 1.23–3.48];). P =.006 There was no protective effect of elective cesarean section (CS) delivery on HCV vertical transmission (adjusted OR, 1.46 [95% CI, 0.86–2.48]; P =.16). HCV/human immunodeficienc virus-coinfected women more frequently transmitted HCV than did women with HCV infection only, although the difference was not statistically significan (adjusted OR, 1.82 [95% CI, 0.94–3.52]; P =.08). Maternal history of injection drug use, prematurity, and breast-feeding were not significantl associated with transmission. Transmission occurred more frequently from viremic women, but it also occurred from a few nonviremic women. Conclusions. Our results strongly suggest that women should neither be offered an elective CS nor be discouraged from breast-feeding on the basis of HCV infection alone. The sex association is an intriguing findin that probably reflect biological differences in susceptibility or response to infection.",

author = "A. Amoroso and F. Asensi-Botet and A. Pereda and V. Balossini and G. Bona and M. Zaffaroni and A. Bandelloni and A. Coscia and C. Fabris and S. Aime and C. Belloni and G. Bossi and B. Salati and C. Boucher and W. Buffolano and K. Butler and {Cabero Roura}, L. and {Bertran Sanges}, {J. M.} and P. Cigna and Ciria, {L. M.} and {Servera Ginard}, C. and {Claret Teruel}, G. and C. Fortuny and O. Coll and A. Corrias and R. Ledda and S. Floris and {De Maria}, A. and J. Echeverria and G. Cilla and M. Lanari and E. Tridapalli and V. Venturi and G. Faldella and B. Fischler and Bohlin, {A. B.} and S. Lindgren and G. Lindh and V. Giacomet and M. Merlo and C. Figini and P. Erba and A. Vigan{\`o} and S. Hannam and G. Mieli-Vergani and A. Hatzakis and C. Inchley and Fjaerli, {H. O.} and A. Maccabruni and M. Marcellini and Sartorelli, {M. R.} and {Martin Fontelos}, P. and A. Mazza and Mok, {J. Y.Q.} and A. M{\^u}r and M. Vi{\~n}olas and Paternoster, {D. M.} and P. Grella and S. Polywka and I. Quinti and Casadei, {A. M.} and A. Rojahn and A. Berg and R. Rosso and S. Ferrando and D. Bassetti and {Ruiz Contreras}, J. and A. Manzanares and {Ruiz Extremera}, A. and F. Salvini and Zuccotti, {G. V.} and T. Schmitz and I. Grosch-W{\"o}rner and {Feiterna Sperling}, C. and T. Piening and A. Vegnente and R. Iorio and A. Versace and S. Garetto and L. Lazier and S. Bressio and C. Riva and A. Alfarano and R. Wejstal and G. Norkrans and A. Zanetti and E. Tanzi and Tovo, {Pier Angelo} and Lucy Pembrey and Newell, {Marie Louise}",

year = "2005",

month = dec,

day = "1",

language = "English",

volume = "61",

pages = "1872--1879",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

number = "4",

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Amoroso, A, Asensi-Botet, F, Pereda, A, Balossini, V, Bona, G, Zaffaroni, M, Bandelloni, A, Coscia, A, Fabris, C, Aime, S, Belloni, C, Bossi, G, Salati, B, Boucher, C, Buffolano, W, Butler, K, Cabero Roura, L, Bertran Sanges, JM, Cigna, P, Ciria, LM, Servera Ginard, C, Claret Teruel, G, Fortuny, C, Coll, O, Corrias, A, Ledda, R, Floris, S, De Maria, A, Echeverria, J, Cilla, G, Lanari, M, Tridapalli, E, Venturi, V, Faldella, G, Fischler, B, Bohlin, AB, Lindgren, S, Lindh, G, Giacomet, V, Merlo, M, Figini, C, Erba, P, Viganò, A, Hannam, S, Mieli-Vergani, G, Hatzakis, A, Inchley, C, Fjaerli, HO, Maccabruni, A, Marcellini, M, Sartorelli, MR, Martin Fontelos, P, Mazza, A, Mok, JYQ, Mûr, A, Viñolas, M, Paternoster, DM, Grella, P, Polywka, S, Quinti, I, Casadei, AM, Rojahn, A, Berg, A, Rosso, R, Ferrando, S, Bassetti, D, Ruiz Contreras, J, Manzanares, A, Ruiz Extremera, A, Salvini, F, Zuccotti, GV, Schmitz, T, Grosch-Wörner, I, Feiterna Sperling, C, Piening, T, Vegnente, A, Iorio, R, Versace, A, Garetto, S, Lazier, L, Bressio, S, Riva, C, Alfarano, A, Wejstal, R, Norkrans, G, Zanetti, A, Tanzi, E, Tovo, PA, Pembrey, L & Newell, ML 2005, 'A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection', Journal of Infectious Diseases, vol. 61, no. 4, pp. 1872-1879.

TY - JOUR

T1 - A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection

AU - Amoroso, A.

AU - Asensi-Botet, F.

AU - Pereda, A.

AU - Balossini, V.

AU - Bona, G.

AU - Zaffaroni, M.

AU - Bandelloni, A.

AU - Coscia, A.

AU - Fabris, C.

AU - Aime, S.

AU - Belloni, C.

AU - Bossi, G.

AU - Salati, B.

AU - Boucher, C.

AU - Buffolano, W.

AU - Butler, K.

AU - Cabero Roura, L.

AU - Bertran Sanges, J. M.

AU - Cigna, P.

AU - Ciria, L. M.

AU - Servera Ginard, C.

AU - Claret Teruel, G.

AU - Fortuny, C.

AU - Coll, O.

AU - Corrias, A.

AU - Ledda, R.

AU - Floris, S.

AU - De Maria, A.

AU - Echeverria, J.

AU - Cilla, G.

AU - Lanari, M.

AU - Tridapalli, E.

AU - Venturi, V.

AU - Faldella, G.

AU - Fischler, B.

AU - Bohlin, A. B.

AU - Lindgren, S.

AU - Lindh, G.

AU - Giacomet, V.

AU - Merlo, M.

AU - Figini, C.

AU - Erba, P.

AU - Viganò, A.

AU - Hannam, S.

AU - Mieli-Vergani, G.

AU - Hatzakis, A.

AU - Inchley, C.

AU - Fjaerli, H. O.

AU - Maccabruni, A.

AU - Marcellini, M.

AU - Sartorelli, M. R.

AU - Martin Fontelos, P.

AU - Mazza, A.

AU - Mok, J. Y.Q.

AU - Mûr, A.

AU - Viñolas, M.

AU - Paternoster, D. M.

AU - Grella, P.

AU - Polywka, S.

AU - Quinti, I.

AU - Casadei, A. M.

AU - Rojahn, A.

AU - Berg, A.

AU - Rosso, R.

AU - Ferrando, S.

AU - Bassetti, D.

AU - Ruiz Contreras, J.

AU - Manzanares, A.

AU - Ruiz Extremera, A.

AU - Salvini, F.

AU - Zuccotti, G. V.

AU - Schmitz, T.

AU - Grosch-Wörner, I.

AU - Feiterna Sperling, C.

AU - Piening, T.

AU - Vegnente, A.

AU - Iorio, R.

AU - Versace, A.

AU - Garetto, S.

AU - Lazier, L.

AU - Bressio, S.

AU - Riva, C.

AU - Alfarano, A.

AU - Wejstal, R.

AU - Norkrans, G.

AU - Zanetti, A.

AU - Tanzi, E.

AU - Tovo, Pier Angelo

AU - Pembrey, Lucy

AU - Newell, Marie Louise

PY - 2005/12/1

Y1 - 2005/12/1

N2 - © 2005 by the Infectious Diseases Society of America. All rights reserved. Background. Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified Methods. We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants. Children with ≥2 positive HCV RNA polymerase chain reaction test results and/or anti-HCV antibodies after 18 months of age were considered to be infected. Results. The overall HCV vertical transmission rate was 6.2% (95% confidenc interval [CI], 5.0%–7.5%; 91/1479). Girls were twice as likely to be infected as boys (adjusted odds ratio [OR], 2.07 [95% CI, 1.23–3.48];). P =.006 There was no protective effect of elective cesarean section (CS) delivery on HCV vertical transmission (adjusted OR, 1.46 [95% CI, 0.86–2.48]; P =.16). HCV/human immunodeficienc virus-coinfected women more frequently transmitted HCV than did women with HCV infection only, although the difference was not statistically significan (adjusted OR, 1.82 [95% CI, 0.94–3.52]; P =.08). Maternal history of injection drug use, prematurity, and breast-feeding were not significantl associated with transmission. Transmission occurred more frequently from viremic women, but it also occurred from a few nonviremic women. Conclusions. Our results strongly suggest that women should neither be offered an elective CS nor be discouraged from breast-feeding on the basis of HCV infection alone. The sex association is an intriguing findin that probably reflect biological differences in susceptibility or response to infection.

AB - © 2005 by the Infectious Diseases Society of America. All rights reserved. Background. Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified Methods. We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants. Children with ≥2 positive HCV RNA polymerase chain reaction test results and/or anti-HCV antibodies after 18 months of age were considered to be infected. Results. The overall HCV vertical transmission rate was 6.2% (95% confidenc interval [CI], 5.0%–7.5%; 91/1479). Girls were twice as likely to be infected as boys (adjusted odds ratio [OR], 2.07 [95% CI, 1.23–3.48];). P =.006 There was no protective effect of elective cesarean section (CS) delivery on HCV vertical transmission (adjusted OR, 1.46 [95% CI, 0.86–2.48]; P =.16). HCV/human immunodeficienc virus-coinfected women more frequently transmitted HCV than did women with HCV infection only, although the difference was not statistically significan (adjusted OR, 1.82 [95% CI, 0.94–3.52]; P =.08). Maternal history of injection drug use, prematurity, and breast-feeding were not significantl associated with transmission. Transmission occurred more frequently from viremic women, but it also occurred from a few nonviremic women. Conclusions. Our results strongly suggest that women should neither be offered an elective CS nor be discouraged from breast-feeding on the basis of HCV infection alone. The sex association is an intriguing findin that probably reflect biological differences in susceptibility or response to infection.

M3 - Article

SN - 0022-1899

VL - 61

SP - 1872

EP - 1879

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection

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