A set of simple cell processes is sufficient to model spiral cleavage

Miguel Brun-Usan, Miquel Marín-Riera, Cristina Grande, Marta Truchado-Garcia, Isaac Salazar-Ciudad

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

© 2017. Published by The Company of Biologists Ltd. During cleavage, different cellular processes cause the zygote to become partitioned into a set of cells with a specific spatial arrangement. These processes include the orientation of cell division according to: an animal-vegetal gradient; the main axis (Hertwig’s rule) of the cell; and the contact areas between cells or the perpendicularity between consecutive cell divisions (Sachs’ rule). Cell adhesion and cortical rotation have also been proposed to be involved in spiral cleavage.We use a computational model of cell and tissue biomechanics to account for the different existing hypotheses about how the specific spatial arrangement of cells in spiral cleavage arises during development. Cell polarization by an animal-vegetal gradient, a bias to perpendicularity between consecutive cell divisions (Sachs’ rule), cortical rotation and cell adhesion, when combined, reproduce the spiral cleavage, whereas other combinations of processes cannot. Specifically, cortical rotation is necessary at the 8-cell stage to direct all micromeres in the same direction. By varying the relative strength of these processes, we reproduce the spatial arrangement of cells in the blastulae of seven different invertebrate species.
Original languageEnglish
Pages (from-to)54-62
JournalDevelopment (Cambridge)
Volume144
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Developmental morphospace
  • Developmental rules
  • Spiral cleavage

Fingerprint Dive into the research topics of 'A set of simple cell processes is sufficient to model spiral cleavage'. Together they form a unique fingerprint.

Cite this