A Scoring System to Determine Risk of Delayed Bleeding After Endoscopic Mucosal Resection of Large Colorectal Lesions

Eduardo Albéniz, María Fraile, Berta Ibáñez, Pedro Alonso-Aguirre, David Martínez-Ares, Santiago Soto, Carla Jerusalén Gargallo, Felipe Ramos Zabala, Marco Antonio Álvarez, Joaquín Rodríguez-Sánchez, Fernando Múgica, Óscar Nogales, Alberto Herreros de Tejada, Eduardo Redondo, Carlos Guarner-Argente, Noel Pin, Helena León-Brito, Remedios Pardeiro, Leopoldo López-Roses, Manuel Rodríguez-TéllezAlejandra Jiménez, Felipe Martínez-Alcalá, Orlando García, Joaquín de la Peña, Akiko Ono, Fernando Alberca de las Parras, María Pellisé, Liseth Rivero, Esteban Saperas, Francisco Pérez-Roldán, Antonio Pueyo Royo, Javier Eguaras Ros, Alba Zúñiga Ripa, Mar Concepción-Martín, Patricia Huelin-Álvarez, Juan Colán-Hernández, Joaquín Cubiella, David Remedios, Xavier Bessa i Caserras, Bartolomé López-Viedma, Julyssa Cobian, Mariano González-Haba, José Santiago, Juan Gabriel Martínez-Cara, Eduardo Valdivielso

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    © 2016 AGA Institute Background & Aims After endoscopic mucosal resection (EMR) of colorectal lesions, delayed bleeding is the most common serious complication, but there are no guidelines for its prevention. We aimed to identify risk factors associated with delayed bleeding that required medical attention after discharge until day 15 and develop a scoring system to identify patients at risk. Methods We performed a prospective study of 1214 consecutive patients with nonpedunculated colorectal lesions 20 mm or larger treated by EMR (n = 1255) at 23 hospitals in Spain, from February 2013 through February 2015. Patients were examined 15 days after the procedure, and medical data were collected. We used the data to create a delayed bleeding scoring system, and assigned a weight to each risk factor based on the β parameter from multivariate logistic regression analysis. Patients were classified as being at low, average, or high risk for delayed bleeding. Results Delayed bleeding occurred in 46 cases (3.7%, 95% confidence interval, 2.7%–4.9%). In multivariate analysis, factors associated with delayed bleeding included age ≥75 years (odds ratio [OR], 2.36; P < .01), American Society of Anesthesiologist classification scores of III or IV (OR, 1.90; P ≤ .05), aspirin use during EMR (OR, 3.16; P < .05), right-sided lesions (OR, 4.86; P < .01), lesion size ≥40 mm (OR, 1.91; P ≤ .05), and a mucosal gap not closed by hemoclips (OR, 3.63; P ≤ .01). We developed a risk scoring system based on these 6 variables that assigned patients to the low-risk (score, 0–3), average-risk (score, 4–7), or high-risk (score, 8–10) categories with a receiver operating characteristic curve of 0.77 (95% confidence interval, 0.70–0.83). In these groups, the probabilities of delayed bleeding were 0.6%, 5.5%, and 40%, respectively. Conclusions The risk of delayed bleeding after EMR of large colorectal lesions is 3.7%. We developed a risk scoring system based on 6 factors that determined the risk for delayed bleeding (receiver operating characteristic curve, 0.77). The factors most strongly associated with delayed bleeding were right-sided lesions, aspirin use, and mucosal defects not closed by hemoclips. Patients considered to be high risk (score, 8–10) had a 40% probability of delayed bleeding.
    Original languageEnglish
    Pages (from-to)1140-1147
    JournalClinical Gastroenterology and Hepatology
    Issue number8
    Publication statusPublished - 1 Aug 2016


    • ASA
    • Colon Cancer
    • Mucosectomy
    • Prognostic Factor


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