A rat mutation producing demyelination (dmy) maps to Chromosome 17

T. Kuramoto; C. Sotelo; N. Yokoi; T. Serikawa; E. Goñalons Sintes; J. Cantó Martorell; J. L. Guénet

doi:https://doi.org/10.1007/s003359900263

A rat mutation producing demyelination (dmy) maps to Chromosome 17

T. Kuramoto, C. Sotelo, N. Yokoi, T. Serikawa, E. Goñalons Sintes, J. Cantó Martorell, J. L. Guénet

Department of Cellular Biology, Physiology and Immunology

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.

Original language	English
Pages (from-to)	890-894
Journal	Mammalian Genome
Volume	7
DOIs	https://doi.org/10.1007/s003359900263
Publication status	Published - 1 Jan 1996

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title = "A rat mutation producing demyelination (dmy) maps to Chromosome 17",

abstract = "A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.",

author = "T. Kuramoto and C. Sotelo and N. Yokoi and T. Serikawa and Sintes, {E. Go{\~n}alons} and Martorell, {J. Cant{\'o}} and Gu{\'e}net, {J. L.}",

year = "1996",

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doi = "https://doi.org/10.1007/s003359900263",

language = "English",

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T1 - A rat mutation producing demyelination (dmy) maps to Chromosome 17

AU - Kuramoto, T.

AU - Sotelo, C.

AU - Yokoi, N.

AU - Serikawa, T.

AU - Sintes, E. Goñalons

AU - Martorell, J. Cantó

AU - Guénet, J. L.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.

AB - A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.

U2 - https://doi.org/10.1007/s003359900263

DO - https://doi.org/10.1007/s003359900263

M3 - Article

SN - 0938-8990

VL - 7

SP - 890

EP - 894

JO - Mammalian Genome

JF - Mammalian Genome

ER -

A rat mutation producing demyelination (dmy) maps to Chromosome 17

Abstract

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