@article{c6bd2fff6e5044f792ac59c68670e087,
title = "A randomized comparison of levobupivacaine, bupivacaine and ropivacaine with fentanyl, for labor analgesia: International Journal of Obstetric Anesthesia",
abstract = "Background: To compare the analgesic efficacy of epidural infusions of levobupivacaine, bupivacaine and ropivacaine in labor. Methods: 102 nulliparous parturients in early labor were enrolled in this randomized, double-blind clinical trial. They were randomly assigned to receive one of three continuous epidural infusion regimens: levobupivacaine 0.125%, bupivacaine 0.125% or ropivacaine 0.2%, all with fentanyl 1 μg/mL at 8 mL/h. Supplementary analgesia was provided with an 8-mL epidural bolus of the study solution if visual analogue scale (VAS) score for pain was ≥40 (0-100 mm). Pain and motor and sensory block were measured at 0, 15 and 30 min, 1, 2, 3 and 4 h and full cervical dilatation. Results: Analgesia was satisfactory in all three groups, with VAS score ",
keywords = "Analgesia: obstetric, epidural, Anesthetics, local: levobupivacaine, bupivacaine, ropivacaine, Opioids: fentanyl, bupivacaine, fentanyl, levobupivacaine, ropivacaine, adult, article, birth, clinical trial, comparative study, continuous infusion, controlled clinical trial, controlled study, double blind procedure, female, human, hypotension, labor, labor pain, labor stage, major clinical study, motor system, nausea, nullipara, obstetric analgesia, pruritus, randomized controlled trial, sensory system, statistical significance, uterine cervix dilatation, visual analog scale, Adjuvants, Anesthesia, Adult, Amides, Analgesia, Epidural, Analgesia, Obstetrical, Analysis of Variance, Anesthetics, Combined, Anesthetics, Local, Bupivacaine, Double-Blind Method, Female, Fentanyl, Humans, Labor Pain, Motor Activity, Pain Measurement, Pregnancy, Treatment Outcome",
author = "M.C. Ati{\'e}nzar and J.Ma. Palanca and F. Torres and R. Borr{\`a}s and S. Gil and I. Esteve",
note = "Cited By :20 Export Date: 17 February 2022 CODEN: IOANE Correspondence Address: Ati{\'e}nzar, M.C.; Department of Anesthesia, , Barcelona, Spain; email: carmen.atienzar@uv.es Chemicals/CAS: bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5; fentanyl, 437-38-7; levobupivacaine, 27262-47-1, 27262-48-2; ropivacaine, 84057-95-4; Adjuvants, Anesthesia; Amides; Anesthetics, Combined; Anesthetics, Local; Bupivacaine, 2180-92-9; Fentanyl, 437-38-7; levobupivacaine; ropivacaine, 84057-95-4 References: Rutten, A.J., Nancarrow, C., Mather, L.A., Isley, A.H., Runciman, W.B., Upton, R.N., Hemodynamic and central nervous system effects of lidocaine, bupivacaine and ropivacaine in sheep (1989) Anesth Analg, 69, pp. 291-299; Huang, Y.F., Pryor, M.E., Mather, L.E., Veering, B.T., Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep (1998) Anesth Analg, 86, pp. 797-804; Morrison, S.G., Dominguez, J.J., Frascarolo, P., Reiz, S., A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine and ropivacaine in anesthetized swine (2000) Anesth Analg, 90, pp. 1308-1314; Lyons, G., Columb, M., Hawthorne, L., Dresner, M., Extradural pain relief labour: bupivacaine sparing by extradural fentanyl is dose dependent (1997) Br J Anaesth, 78, pp. 493-497; Robinson, A.P., Lyons, G.R., Wilson, R.C., Gorton, H.J., Columb, M.O., Levobupivacaine for extradural analgesia in labor; the sparing effect of epidural fentanyl (2001) Anesth Analg, 92, pp. 410-414; Atienzar, M.C., Palanca, J.M., Borras, R., Esteve, I., Fernandez, M., Miranda, A., Ropivacaine 0.1% with fentanyl 2 μg/mL by epidural infusion for labour analgesia (2004) Eur J Anaesthesiol, 21, pp. 770-775; The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. The Lancet 2001; 357: 1191-4; Lyons, G., Columb, M., Wilson, R.C., Johnson, R.V., Epidural pain relief in labour: potencies of levobupivacaine and racemic bupivacaine (1998) Br J Anaesth, 81, pp. 899-901; Caponga, G., Celleno, D., Fusco, P., Lyons, G., Columb, M., Relative potencies of bupivacaine and ropivacaine for analgesia in labour (1999) Br J Anaesth, 82, pp. 371-373; Schug, S.A., Correction factor for comparison between levobupivacaine and racemic bupivacaine (2001) Reg Anesth Pain Med, 26, p. 91; Benhamou, D., Ghosh, C., Mercier, F.J., A randomized sequential allocation study to determine the minimum effective analgesic concentration of levobupivacaine and ropivacaine in patients receiving epidural analgesia for labor (2003) Anesthesiology, 99, pp. 1383-1386; Polley, L.S., Columb, M.O., Naughton, N.N., Wagner, D.S., van de Ven, C.J., Goralski, K.H., Relative analgesic potencies of levobupivacaine and ropivacaine for epidural analgesia in labor (2003) Anesthesiology, 99, pp. 1354-1358; Purdie, N.L., McGrady, E.M., Comparison of patient-controlled epidural bolus administration of 0,1% ropivacaine and 0,1% levobupivacaine, both with 0.0002% fentanyl for analgesia during labour (2004) Anaesthesia, 59, pp. 133-137; Supandji, M., Sia, A.T.H., Ocampo, C.E., 0,2% ropivacaine and levobupivacaine provide equally effective epidural labor analgesia (2004) Can J Anesth, 51, pp. 918-922; Lacassie, H.J., Columb, M.O., The relative motor blocking potencies of bupivacaine and levobupivacaine in labor (2003) Anesth Analg, 97, pp. 1509-1513; Lim, Y., Ocampo, C.E., Sia, A.T., A comparison of duration of analgesia of intratecal 2.5 mg of bupivacaine, ropivacaine and levobupivacaine in combined spinal epidural analgesia for patients in labor (2004) Anesth Analg, 98, pp. 235-239; Camorcia, M., Capogna, G., Epidural levobupivacaine, ropivacaine and bupivacaine in combination with sufentanil in early labour: a randomized trial (2003) Eur J Anaesthesiol, 20, pp. 636-639; Burke, D., Henderson, D.J., Simpson, A.M., Comparison of 0.25% S(-)-bupivacaine with RS-bupivacaine for epidural analgesia in labour (1999) Br J Anaesth, 83, pp. 750-755",
year = "2008",
month = apr,
doi = "10.1016/j.ijoa.2007.10.003",
language = "English",
volume = "17",
pages = "106--111",
journal = "International Journal of Obstetric Anesthesia",
issn = "0959-289X",
number = "2",
}