A randomized comparison of levobupivacaine, bupivacaine and ropivacaine with fentanyl, for labor analgesia: International Journal of Obstetric Anesthesia

M.C. Atiénzar, J.Ma. Palanca, F. Torres, R. Borràs, S. Gil, I. Esteve

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Background: To compare the analgesic efficacy of epidural infusions of levobupivacaine, bupivacaine and ropivacaine in labor. Methods: 102 nulliparous parturients in early labor were enrolled in this randomized, double-blind clinical trial. They were randomly assigned to receive one of three continuous epidural infusion regimens: levobupivacaine 0.125%, bupivacaine 0.125% or ropivacaine 0.2%, all with fentanyl 1 μg/mL at 8 mL/h. Supplementary analgesia was provided with an 8-mL epidural bolus of the study solution if visual analogue scale (VAS) score for pain was ≥40 (0-100 mm). Pain and motor and sensory block were measured at 0, 15 and 30 min, 1, 2, 3 and 4 h and full cervical dilatation. Results: Analgesia was satisfactory in all three groups, with VAS score
Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalInternational Journal of Obstetric Anesthesia
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Analgesia: obstetric, epidural
  • Anesthetics, local: levobupivacaine, bupivacaine, ropivacaine
  • Opioids: fentanyl
  • bupivacaine
  • fentanyl
  • levobupivacaine
  • ropivacaine
  • adult
  • article
  • birth
  • clinical trial
  • comparative study
  • continuous infusion
  • controlled clinical trial
  • controlled study
  • double blind procedure
  • female
  • human
  • hypotension
  • labor
  • labor pain
  • labor stage
  • major clinical study
  • motor system
  • nausea
  • nullipara
  • obstetric analgesia
  • pruritus
  • randomized controlled trial
  • sensory system
  • statistical significance
  • uterine cervix dilatation
  • visual analog scale
  • Adjuvants, Anesthesia
  • Adult
  • Amides
  • Analgesia, Epidural
  • Analgesia, Obstetrical
  • Analysis of Variance
  • Anesthetics, Combined
  • Anesthetics, Local
  • Bupivacaine
  • Double-Blind Method
  • Female
  • Fentanyl
  • Humans
  • Labor Pain
  • Motor Activity
  • Pain Measurement
  • Pregnancy
  • Treatment Outcome

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