A Personalized Approach to Determining the Caloric Needs of Children with Prader-Willi Syndrome Treated with Growth Hormone

Assumpta Caixàs i Pedragós, Raquel Corripio, Yolanda Couto-Rosende, Diana Garcia-Tirado, Mónica Palacio-Marco

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Prader-Willi Syndrome (PWS) is the most frequent cause of genetic obesity. Early reports indicate that children with PWS require 20-40% fewer calories than healthy children to maintain adequate growth. Growth hormone treatment for children with PWS, approved in 2000, affects the body composition and probably affects energy requirements. This retrospective cross-sectional study analyzed the caloric intake in children with PWS aged from 6 months to 12 years old who underwent growth hormone treatment, comparing the patients' caloric intake calculated from parent-recorded dietary intake versus the recommended caloric intake for healthy children, taking into account the age, sex, height, weight, and physical activity. We analyzed the data from 25 patients (13 (52%) boys; mean age, 6.72 ± 2.81 y; median age at starting growth hormone treatment, 1.4 y (IQR: 0.78-2.29); 17 (68%) normal weight and 8 (32%) overweight or obese). The mean daily energy intake was 1208 ± 186 kcal/d, representing 96.83% ± 18.66 of the recommended caloric intake for healthy children. The caloric intake in children with PWS treated with growth hormone was very similar to that recommended for healthy children; thus, we should rethink the dietary recommendations for these children.
Original languageEnglish
Article number3967
JournalJournal of Clinical Medicine
Volume12
Issue number12
DOIs
Publication statusPublished - 10 Jun 2023

Keywords

  • Caloric intake
  • Childhood
  • Dietary record
  • Growth hormone
  • Prader-Willi syndrome

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