A panel of multibiomarkers of inflammation, fibrosis, and catabolism is normal in healthy centenarians but has high values in young patients with myocardial infarction

Lourdes Vicent, Helena Martínez-Sellés, Albert Ariza-Solé, Alejandro Lucia, Enzo Emanuele, Antoni Bayés-Genís, Francisco Fernández-Avilés, Manuel Martínez-Sellés

Research output: Contribution to journalArticleResearch

1 Citation (Scopus)

Abstract

© 2018 Elsevier B.V. Objectives: Frailty confers a poor prognosis as it portends an increased risk of disability, dependence, and mortality. Although frailty is generally associated with aging, a marked interindividual variability exists. We compared a range of serum biomarkers of inflammation, fibrosis, and catabolism in three distinct cohorts, consisting of young patients with myocardial infarction, age-matched healthy volunteers, and disease-free centenarians. Study design: Prospective observational registry study. Main outcome measures: Serum levels of five biomarkers were measured in the three study groups. Results: Disease-free centenarians had significantly lower (all p < 0.01) serum biomarker levels than young patients with myocardial infarction (growth differentiation factor 15: 877 ± 299 vs. 1062 ± 358 pg/mL; matrix metalloproteinase (MMP)-1: 1.7 ± 0.9 vs. 3.2 ± 1.2 ng/mL; MMP-2 174 ± 38 vs. 214 ± 44 ng/mL; MMP-9 325 ± 73 vs. 407 ± 54 ng/mL; and carboxy-terminal telopeptide of collagen type I: 3.3 ± 1 vs. 4.2 ± 1.3 ng/mL). No significant differences in biomarker concentrations between healthy controls and centenarians were identified. Conclusions: Disease-free centenarians had significantly lower levels of inflammation, fibrosis, and catabolism biomarkers than young patients with myocardial infarction. Advanced aging per se is not invariably associated with these biomarkers.
Original languageEnglish
Pages (from-to)54-58
JournalMaturitas
Volume116
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Aging
  • Biomarkers
  • Cardiovascular risk
  • Centenarians
  • Frailty

Fingerprint Dive into the research topics of 'A panel of multibiomarkers of inflammation, fibrosis, and catabolism is normal in healthy centenarians but has high values in young patients with myocardial infarction'. Together they form a unique fingerprint.

Cite this