TY - JOUR
T1 - A novel spongiform degeneration of the grey matter in the brain of a kitten
AU - Vidal Barba, Enric
AU - Montoliu, P.
AU - Añor Torres, Sonia
AU - Sisó, S.
AU - Ferrer, I.
AU - Pumarola Batlle, Marti
PY - 2004/1/1
Y1 - 2004/1/1
N2 - A young female domestic short-hair cat presented with neurological signs consistent with a multifocal encephalic lesion (depressed mental status, head tilt to the right, cervical ventroflexion, head tremors, tetraparesis, conscious propioceptive deficits in all four limbs and visual deficits). No gross lesions were seen at necropsy. On light microscopical examination lesions were found only in the brain and cervical spinal cord. A generalized vacuolation of the grey matter of the brain was observed. Special staining techniques, immunohistochemistry, lectin affinity histochemistry and ultrastructural studies were performed to characterize the lesion; preservation of the white matter and a reactive astrogliosis were demonstrated. Feline retroviruses and PrPsc were not detected. Ultrastructurally, a dilatation of intracytoplasmic membrane-bounded organelles with membrane disruption and dendritic and somatic swelling was found in astrocytes and neurons. The age of the animal and histological changes suggested a novel, possibly congenital, spongiform degeneration of the brain and cervical spinal cord. © 2004 Elsevier Ltd. All rights reserved.
AB - A young female domestic short-hair cat presented with neurological signs consistent with a multifocal encephalic lesion (depressed mental status, head tilt to the right, cervical ventroflexion, head tremors, tetraparesis, conscious propioceptive deficits in all four limbs and visual deficits). No gross lesions were seen at necropsy. On light microscopical examination lesions were found only in the brain and cervical spinal cord. A generalized vacuolation of the grey matter of the brain was observed. Special staining techniques, immunohistochemistry, lectin affinity histochemistry and ultrastructural studies were performed to characterize the lesion; preservation of the white matter and a reactive astrogliosis were demonstrated. Feline retroviruses and PrPsc were not detected. Ultrastructurally, a dilatation of intracytoplasmic membrane-bounded organelles with membrane disruption and dendritic and somatic swelling was found in astrocytes and neurons. The age of the animal and histological changes suggested a novel, possibly congenital, spongiform degeneration of the brain and cervical spinal cord. © 2004 Elsevier Ltd. All rights reserved.
KW - Brain
KW - Cat
KW - Spinal cord
KW - Spongiform degeneration
U2 - https://doi.org/10.1016/j.jcpa.2004.01.007
DO - https://doi.org/10.1016/j.jcpa.2004.01.007
M3 - Article
VL - 131
SP - 98
EP - 103
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
ER -