A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data

Sandra Ortega-Martorell, Héctor Ruiz, Alfredo Vellido, Iván Olier, Enrique Romero, Margarida Julià-Sapé, José D. Martín, Ian H. Jarman, Carles Arús, Paulo J.G. Lisboa

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)


Background: The clinical investigation of human brain tumors often starts with a non-invasive imaging study, providing information about the tumor extent and location, but little insight into the biochemistry of the analyzed tissue. Magnetic Resonance Spectroscopy can complement imaging by supplying a metabolic fingerprint of the tissue. This study analyzes single-voxel magnetic resonance spectra, which represent signal information in the frequency domain. Given that a single voxel may contain a heterogeneous mix of tissues, signal source identification is a relevant challenge for the problem of tumor type classification from the spectroscopic signal. Methodology/Principal Findings: Non-negative matrix factorization techniques have recently shown their potential for the identification of meaningful sources from brain tissue spectroscopy data. In this study, we use a convex variant of these methods that is capable of handling negatively-valued data and generating sources that can be interpreted as tumor class prototypes. A novel approach to convex non-negative matrix factorization is proposed, in which prior knowledge about class information is utilized in model optimization. Class-specific information is integrated into this semi-supervised process by setting the metric of a latent variable space where the matrix factorization is carried out. The reported experimental study comprises 196 cases from different tumor types drawn from two international, multi-center databases. The results indicate that the proposed approach outperforms a purely unsupervised process by achieving near perfect correlation of the extracted sources with the mean spectra of the tumor types. It also improves tissue type classification. Conclusions/Significance: We show that source extraction by unsupervised matrix factorization benefits from the integration of the available class information, so operating in a semi-supervised learning manner, for discriminative source identification and brain tumor labeling from single-voxel spectroscopy data. We are confident that the proposed methodology has wider applicability for biomedical signal processing. © 2013 Ortega-Martorell et al.
Original languageEnglish
Article numbere83773
JournalPLoS ONE
Publication statusPublished - 23 Dec 2013


Dive into the research topics of 'A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data'. Together they form a unique fingerprint.

Cite this