A novel electronic tongue using electropolymerized molecularly imprinted polymers for the simultaneous determination of active pharmaceutical ingredients

Mingyue Wang, Xavier Cetó, Manel del Valle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The combination of chemometrics and electrochemical sensors modified with molecularly imprinted polymers (MIPs) towards the development of MIP-based electronic tongues (ETs) was explored herein. To demonstrate the potential of such an approach, the simultaneous determination of paracetamol, ascorbic acid and uric acid mixtures in pharmaceutical samples was evaluated. To this aim, MIP-based sensors for the different compounds were prepared by in situ electropolymerization of pyrrole in the presence of p-toluenesulfonate anion (pTS−), which acted as functional doping ion of the polypyrrole (PPy) MIP backbone. Morphological characterization of the MIPs was done by scanning electron microscopy (SEM), while functionalization of the electrodes was monitored electrochemically. Under the optimized measuring conditions, the developed sensors showed a good performance, with good linearity at the μM level (R2 > 0.992, limits of detection between 1 and 24 μM) as well as good repeatability (intra- and inter-day RSD values between 3 and 6% over 30 consecutive measurements). Finally, the quantification of the individual substances in different pharmaceutical samples was achieved by an artificial neural networks (ANNs) model, showing satisfactory agreement between expected and obtained values (R2 > 0.987).
Original languageEnglish
Article number113807
Pages (from-to)113807
Number of pages9
JournalBiosensors and Bioelectronics
Volume198
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • Artificial neural networks
  • Biosensing Techniques
  • Chemometrics
  • Electrochemical Techniques
  • Electrochemical sensors
  • Electrodes
  • Electronic Nose
  • Electronic tongues
  • Molecular Imprinting
  • Molecularly Imprinted Polymers
  • Molecularly imprinted polymers
  • Pharmaceutical Preparations
  • Pharmaceutical analysis
  • Polymers
  • Pyrroles

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