A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy

Ricard Rojas-Garcia, Maria Martinez-Lage, Eduard Gallardo, Noemi de Luna, Josep Lluis Marti-Vilalta, Jordi Diaz-Manera, Candido Juarez, Rafael Blesa, Isabel Illa

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7 Citations (Scopus)

Abstract

We describe a patient with acute oropharyngeal-facial diplegia, tongue palsy and albuminocytological dissociation following upper respiratory tract infection. Electrophysiological abnormalities in blink reflex suggested a brainstem lesion. High titers of anti-GM3, GD1a and GT1b IgG class serum antibodies were initially detected. Absorption studies indicated that antibodies were directed to a common terminal epitope NeuNAc(alfa 2-3)Gal. This novel antiganglioside antibody specificity may play a role in this unusual regional form of acute bulbar palsy of possible central origin. These data are supportive for extending the panel of antiganglioside specificities with anti-GM3. © 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)219-222
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
Publication statusPublished - 1 Jul 2006

Keywords

  • Acute bulbar palsy
  • Antiganglioside antibodies
  • GD1a
  • GM3
  • GT1b

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