A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples

Manuel Higueras, J. E. González, Marina Di Giorgio, J. F. Barquinero

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2018, Copyright © 2018 Taylor & Francis Group LLC. Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations in blood cells comes from an homogeneous or inhomogeneous exposure. Materials and methods: Three Poisson exact goodness-of-fit test from the literature are introduced and implemented in the R environment. A Shiny R Studio application, named GOF Poisson, has been updated for the purpose of giving support to this work. The three exact tests and the u-test are applied in chromosomal aberration data from clinical and accidental radiation exposure patients. Results: It is observed how the u-test is not an appropriate approximation in small samples with small yield of chromosomal aberrations. Tools are provided to compute the three exact tests, which is not as trivial as the implementation of the u-test. Conclusions: Poisson exact goodness-of-fit tests should be considered jointly to the u-test for detecting inhomogeneous exposures in the cytogenetic biodosimetry practice.
Original languageEnglish
Pages (from-to)656-663
JournalInternational Journal of Radiation Biology
Volume94
Issue number7
DOIs
Publication statusPublished - 31 May 2018

Keywords

  • Exact tests
  • chromosomal aberrations
  • dispersion index
  • frequency of zero counts
  • homogeneity

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