A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis

F. David Carmona, Aurora Serrano, Luis Rodríguez-Rodríguez, Santos Castañeda, José A. Miranda-Filloy, Inmaculada C. Morado, Javier Narváez, Roser Solans, Bernardo Sopeña, Begoña Marí-Alfonso, Ainhoa Unzurrunzaga, Norberto Ortego-Centeno, Ricardo Blanco, Eugenio De Miguel, Ana Hidalgo-Conde, Javier Martín, Miguel A. González-Gay

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Objective. To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). Methods. A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. Results. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA. Conclusion. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA. The Journal of Rheumatology Copyright © 2011. All rights reserved.
Original languageEnglish
Pages (from-to)2598-2601
JournalJournal of Rheumatology
Volume38
Issue number12
DOIs
Publication statusPublished - 1 Dec 2011

Keywords

  • Giant cell arteritis
  • ITGAM rs1143679
  • Single-nucleotide polymorphism
  • Temporal arteritis

Fingerprint

Dive into the research topics of 'A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis'. Together they form a unique fingerprint.

Cite this