A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae

Jordi Corral Sábado; Maria Perez Varela; Marc Gaona Soler; Susana Campoy Sanchez; Jordi Barbe Garcia; Jesus Aranda Rodriguez

doi:10.1128/aac.01644-25

A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae

Jordi Corral Sábado^*, Maria Perez Varela, Marc Gaona Soler, Susana Campoy Sanchez, Jordi Barbe Garcia, Jesus Aranda Rodriguez

^*Corresponding author for this work

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. In a recent work, we identified a novel Major Facilitator Superfamily efflux system in Acinetobacter baumannii, designated SxtPR, which mediates antimicrobial resistance and pathogenicity (M. Gaona, J. Corral, S. Campoy, J. Barbé, et al, Antimicrob Agents Chemother e0071224, 2024, https://doi.org/10.1128/aac.00712-24). Here, we report the identification and characterization of a homologous system in Klebsiella pneumoniae that plays a similar dual role in antimicrobial resistance and virulence.

Original language	English
Article number	e0164425.
Pages (from-to)	e0164425
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	18
DOIs	https://doi.org/10.1128/aac.01644-25
Publication status	Published - 18 Jun 2026

Keywords

Klebsiella pneumoniae
LysR-type transcriptional regulator
MFS efflux pump

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A newly identified homologous SxtPR efflux system contributes to sulfamethoxazoletrimethoprim susceptibility and pathogenesis in Klebsiella pneumoniaeFinal published version, 743 KB

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Cite this

Corral Sábado, J., Perez Varela, M., Gaona Soler, M., Campoy Sanchez, S., Barbe Garcia, J., & Aranda Rodriguez, J. (2026). A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 18, e0164425. Article e0164425. https://doi.org/10.1128/aac.01644-25

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title = "A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae",

abstract = "Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. In a recent work, we identified a novel Major Facilitator Superfamily efflux system in Acinetobacter baumannii, designated SxtPR, which mediates antimicrobial resistance and pathogenicity (M. Gaona, J. Corral, S. Campoy, J. Barb{\'e}, et al, Antimicrob Agents Chemother e0071224, 2024, https://doi.org/10.1128/aac.00712-24). Here, we report the identification and characterization of a homologous system in Klebsiella pneumoniae that plays a similar dual role in antimicrobial resistance and virulence.",

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author = "\{Corral S{\'a}bado\}, Jordi and \{Perez Varela\}, Maria and \{Gaona Soler\}, Marc and \{Campoy Sanchez\}, Susana and \{Barbe Garcia\}, Jordi and \{Aranda Rodriguez\}, Jesus",

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Corral Sábado, J , Perez Varela, M, Gaona Soler, M, Campoy Sanchez, S , Barbe Garcia, J & Aranda Rodriguez, J 2026, 'A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae', Antimicrobial Agents and Chemotherapy, vol. 18, e0164425., pp. e0164425. https://doi.org/10.1128/aac.01644-25

A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae. / Corral Sábado, Jordi ; Perez Varela, Maria; Gaona Soler, Marc et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 18, e0164425., 18.06.2026, p. e0164425.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Campoy Sanchez, Susana

AU - Barbe Garcia, Jordi

AU - Aranda Rodriguez, Jesus

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